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Articles Published Processes
9/28/2018 12:52:44 AM | Browse: 1019 | Download: 1131
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Received |
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2018-06-21 03:11 |
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Peer-Review Started |
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2018-06-21 08:43 |
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To Make the First Decision |
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2018-07-19 07:47 |
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Return for Revision |
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2018-07-23 06:39 |
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Revised |
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2018-08-01 17:17 |
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Second Decision |
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2018-08-18 04:34 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-08-21 21:10 |
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Articles in Press |
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2018-08-21 21:10 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-08-30 18:10 |
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Typeset the Manuscript |
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2018-09-27 02:38 |
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Publish the Manuscript Online |
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2018-09-28 00:52 |
| ISSN |
2150-5330 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kaylene Barrera, Albert Stanek, Kei Okochi, Zuzanna Niewiadomska, Cathy Mueller, Peiqi Ou, Devon John, Antonio E Alfonso, Scott Tenner and Chongmin Huan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Chongmin Huan, MD, PhD, Assistant Professor, Department of Surgery and Cell Biology, State University of New York, Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, United States. chongmin.huan@downstate.edu |
| Key Words |
Acute pancreatitis; Endoplasmic reticulum stress; Unfolded protein response; Acinar cell injury; Autophagy |
| Core Tip |
The widely-accepted autodigestion theory of acute pancreatitis (AP) has been considerably modified by the recent recognition of endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR) as an essential self-protective activity in acinar cells. Inadequate UPR, however, leads to acinar cell injury in AP with elusive mechanisms. We review the relevant literature and propose mechanistic models with the hope of facilitating the research required for the development of effective AP treatment. |
| Publish Date |
2018-09-28 00:52 |
| Citation |
Barrera K, Stanek A, Okochi K, Niewiadomska Z, Mueller C, Ou P, John D, Alfonso AE, Tenner S, Huan C. Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis. World J Gastrointest Pathophysiol 2018; 9(2): 37-46 |
| URL |
http://www.wjgnet.com/2150-5330/full/v9/i2/37.htm |
| DOI |
http://dx.doi.org/10.4291/wjgp.v9.i2.37 |
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