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Publication Name World Journal of Clinical Cases
Manuscript ID 40349
Country/Territory China
Received
2018-06-19 00:35
Peer-Review Started
2018-06-19 01:09
To Make the First Decision
2018-07-12 00:28
Return for Revision
2018-07-13 02:25
Revised
2018-07-27 15:19
Second Decision
2018-08-02 11:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-08-04 05:33
Articles in Press
2018-08-04 05:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-08-11 22:45
Typeset the Manuscript
2018-09-21 02:18
Publish the Manuscript Online
2018-09-26 09:00
ISSN 2307-8960 (online)
Open Access Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title PNPLA3 rs139051 is associated with phospholipid metabolite profile and hepatic inflammation in nonalcoholic fatty liver disease
Manuscript Source Unsolicited Manuscript
All Author List Ji-Jun Luo, Hai-Xia Cao, Rui-Xu Yang, Rui-Nan Zhang and Qin Pan
ORCID
Author(s) ORCID Number
Ji-Jun Luo http://orcid.org/0000-0002-3007-935X
Hai-Xia Cao http://orcid.org/0000-0002-8265-9460
Rui-Xu Yang http://orcid.org/0000-0001-9384-6408
Rui-Nan Zhang http://orcid.org/0000-0001-9049-3010
Qin Pan http://orcid.org/0000-0001-5855-4952
Funding Agency and Grant Number
Funding Agency Grant Number
National Key Research and Development Plan ‘Precision Medicine Research’ 2017YFC0908903
National Natural Science Foundation of China 81070346
National Natural Science Foundation of China 81270492
National Natural Science Foundation of China 81470859
National Natural Science Foundation of China 81270491
National Natural Science Foundation of China 81470840
State Key Development Program for Basic Research of China 2012CB517501
100 Talents Program XBR2011007h
Program of the Committee of Science and Technology 09140903500
Corresponding Author Qin Pan, MD, PhD, Professor, Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Kongjiang Road NO 1665, Yangpu District, Shanghai 200092, China. panqin@xinhuamed.com.cn
Key Words Nonalcoholic fatty liver disease; Patatin-like phospholipase domain containing 3; Single nucleotide polymorphism; Phospholipid; Inflammation
Core Tip PNPLA3 single nucleotide polymorphisms reflect an important genetic basis of serum lipidomics, especially phospholipid metabolites, in nonalcoholic fatty liver disease (NAFLD) patients. PNPLA3 rs139051 (A/A genotype) exerts an up-regulatory effect on phospholipids of lysophosphatidylcholines (LPCs) and lysophosphatidylcholine plasmalogens (LPCOs). Moreover, both the A/A genotype at PNPLA3 rs139051 and high-level LPCs/LPCOs share an association with the low-grade lobular inflammation of NAFLD. Therefore, PNPLA3 rs139051 may underlie the inflammatory progress of NAFLD with its modulation of phospholipid metabolite profiles.
Publish Date 2018-09-26 09:00
Citation Luo JJ, Cao HX, Yang RX, Zhang RN, Pan Q. PNPLA3 rs139051 is associated with phospholipid metabolite profile and hepatic inflammation in nonalcoholic fatty liver disease. World J Clin Cases 2018; 6(10): 355-364
URL http://www.wjgnet.com/2307-8960/full/v6/i10/355.htm
DOI http://dx.doi.org/10.12998/wjcc.v6.i10.355
Full Article (PDF) WJCC-6-355.pdf
Full Article (Word) WJCC-6-355.doc
Manuscript File 40349-Review.doc
Answering Reviewers 40349-Answering Reviewers.pdf
Audio Core Tip 40349-Audio core tip.m4a
Biostatistics Review Certificate 40349-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 40349-Conflict-of-interest statement.pdf
Copyright License Agreement 40349-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 40349-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 40349-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 40349-Language certificate.pdf
Peer-review Report 40349-Peer-review(s).pdf
Scientific Misconduct Check 40349-Scientific misconduct check.pdf
Scientific Editor Work List 40349-Scientific editor work list.pdf