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Articles Published Processes
9/26/2018 9:00:43 AM | Browse: 1014 | Download: 1751
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Received |
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2018-06-19 00:35 |
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Peer-Review Started |
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2018-06-19 01:09 |
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To Make the First Decision |
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2018-07-12 00:28 |
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Return for Revision |
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2018-07-13 02:25 |
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Revised |
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2018-07-27 15:19 |
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Second Decision |
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2018-08-02 11:30 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-08-04 05:33 |
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Articles in Press |
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2018-08-04 05:33 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-08-11 22:45 |
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Typeset the Manuscript |
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2018-09-21 02:18 |
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Publish the Manuscript Online |
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2018-09-26 09:00 |
| ISSN |
2307-8960 (online) |
| Open Access |
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
PNPLA3 rs139051 is associated with phospholipid metabolite profile and hepatic inflammation in nonalcoholic fatty liver disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ji-Jun Luo, Hai-Xia Cao, Rui-Xu Yang, Rui-Nan Zhang and Qin Pan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Research and Development Plan ‘Precision Medicine Research’ |
2017YFC0908903 |
| National Natural Science Foundation of China |
81070346 |
| National Natural Science Foundation of China |
81270492 |
| National Natural Science Foundation of China |
81470859 |
| National Natural Science Foundation of China |
81270491 |
| National Natural Science Foundation of China |
81470840 |
| State Key Development Program for Basic Research of China |
2012CB517501 |
| 100 Talents Program |
XBR2011007h |
| Program of the Committee of Science and Technology |
09140903500 |
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| Corresponding Author |
Qin Pan, MD, PhD, Professor, Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Kongjiang Road NO 1665, Yangpu District, Shanghai 200092, China. panqin@xinhuamed.com.cn |
| Key Words |
Nonalcoholic fatty liver disease; Patatin-like phospholipase domain containing 3; Single nucleotide polymorphism; Phospholipid; Inflammation |
| Core Tip |
PNPLA3 single nucleotide polymorphisms reflect an important genetic basis of serum lipidomics, especially phospholipid metabolites, in nonalcoholic fatty liver disease (NAFLD) patients. PNPLA3 rs139051 (A/A genotype) exerts an up-regulatory effect on phospholipids of lysophosphatidylcholines (LPCs) and lysophosphatidylcholine plasmalogens (LPCOs). Moreover, both the A/A genotype at PNPLA3 rs139051 and high-level LPCs/LPCOs share an association with the low-grade lobular inflammation of NAFLD. Therefore, PNPLA3 rs139051 may underlie the inflammatory progress of NAFLD with its modulation of phospholipid metabolite profiles. |
| Publish Date |
2018-09-26 09:00 |
| Citation |
Luo JJ, Cao HX, Yang RX, Zhang RN, Pan Q. PNPLA3 rs139051 is associated with phospholipid metabolite profile and hepatic inflammation in nonalcoholic fatty liver disease. World J Clin Cases 2018; 6(10): 355-364 |
| URL |
http://www.wjgnet.com/2307-8960/full/v6/i10/355.htm |
| DOI |
http://dx.doi.org/10.12998/wjcc.v6.i10.355 |
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