Publication Name	World Journal of Critical Care Medicine
Manuscript ID	40412
Country	United States

Received	2018-06-24 23:58
Peer-Review Started	2018-06-25 03:16
To Make the First Decision	2018-07-09 08:07
Return for Revision	2018-07-11 01:59
Revised	2018-08-04 02:32
Second Decision	2018-08-18 06:30
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-08-21 20:54
Articles in Press	2018-08-21 20:54
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-08-29 17:14
Typeset the Manuscript	2018-10-10 10:45
Publish the Manuscript Online	2018-10-15 07:43

ISSN	2220-3141(online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Critical Care Medicine
Manuscript Type	Review
Article Title	Vitamin C in the critically ill - indications and controversies
Manuscript Source	Invited Manuscript
All Author List	Christoph S Nabzdyk and Edward A Bittner
ORCID	Author(s) ORCID Number Christoph S Nabzdyk http://orcid.org/0000-0002-9849-6221 Edward A Bittner http://orcid.org/0000-0002-0159-2373
Funding Agency and Grant Number
Corresponding Author	Edward A Bittner, FACE, FCCP, MD, PhD, Associate Professor, Staff Physician, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114, United States. ebittner@partners.org
Key Words	Ascorbic acid; vitamin C; Sepsis; Shock; Critical care medicine; Vasopressors; Cardiovascular
Core Tip	An increasing body of evidence suggests that high-dose vitamin C administration improves hemo­dynamics, end-organ function, and may improve survival in critically ill patients. This article reviews studies that evaluate vitamin C in pre-clinical models and clinical trials with respect to its therapeutic potential.
Publish Date	2018-10-15 07:43
Citation	Nabzdyk CS, Bittner EA. Vitamin C in the critically ill - indications and controversies. World J Crit Care Med 2018; 7(5): 52-61
URL	http://www.wjgnet.com/2220-3141/full/v7/i5/52.htm
DOI	http://dx.doi.org/10.5492/wjccm.v7.i5.52

Full Article (PDF)	WJCCM-7-52.pdf
Manuscript File	40412-Review.docx
Answering Reviewers	40412-Answering reviewers.pdf
Audio Core Tip	40412-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	40412-Conflict-of-interest statement.pdf
Copyright License Agreement	40412-Copyright license agreement.pdf
Peer-review Report	40412-Peer-review(s).pdf
Scientific Misconduct Check	40412-Scientific misconduct check.pdf
Scientific Editor Work List	40412-Scientific editor work list.pdf