Publication Name	World Journal of Gastroenterology
Manuscript ID	40423
Country	India

Received	2018-06-23 10:11
Peer-Review Started	2018-06-24 09:09
To Make the First Decision	2018-07-04 01:15
Return for Revision	2018-07-06 01:28
Revised	2018-07-23 11:40
Second Decision	2018-07-31 12:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-08-01 04:18
Articles in Press	2018-08-01 04:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-09-17 01:05
Publish the Manuscript Online	2018-09-20 02:33

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Pathology
Manuscript Type	Review
Article Title	Changing role of histopathology in the diagnosis and management of hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Archana Rastogi
ORCID	Author(s) ORCID Number Archana Rastogi http://orcid.org/0000-0001-9669-3961
Funding Agency and Grant Number
Corresponding Author	Archana Rastogi, DNB, MBBS, MD, Professor, Department of Pathology, Institute of Liver & Biliary Sciences, D-1, Vasant Kunj,, New Delhi 110070, India. drarchanarastogi@gmail.com
Key Words	Hepatocellular carcinoma; Biomarker; Biopsy; Histopathology; Immunohistochemistry; Targeted therapy; Molecular; Diagnosis; Prognosis
Core Tip	Liver biopsy plays important roles in the diagnosis and prognosis of hepatocellular carcinoma. However biopsy related complications and limitations along with advancements in imaging have restricted its role to very limited situations. In recent time, studies on tissue biomarkers, molecular classifications and tar­geted therapies for hepatocellular carcinoma (HCC) with their clinic-pathologic correlations have highlighted that morphologic variants and subtypes can serve as importance surrogates of molecular signatures, thus re­newing the interest in tissue analysis. Tumor biopsy thus is increasingly being recognized as an invaluable tool for the diagnosis, management and prognostication of HCC.
Publish Date	2018-09-20 02:33
Citation	Rastogi A. Changing role of histopathology in the diagnosis and management of hepatocellular carcinoma. World J Gastroenterol 2018; 24(35): 4000-4013
URL	http://www.wjgnet.com/1007-9327/full/v24/i35/4000.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i35.4000

Full Article (PDF)	WJG-24-4000.pdf
Manuscript File	40423-Review.docx
Answering Reviewers	40423-Answering reviewers.pdf
Audio Core Tip	40423-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	40423-Conflict-of-interest statement.pdf
Copyright License Agreement	40423-Copyright license agreement.PDF
Non-Native Speakers of English Editing Certificate	40423-Non-Native-Speakers-of-English-Editing-Certificate-revision.PDF
Peer-review Report	40423-Peer-review(s).pdf
Scientific Misconduct Check	40423-Scientific misconduct check.pdf
Scientific Editor Work List	40423-Scientific editor work list.pdf