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Articles Published Processes
12/14/2018 1:19:57 AM | Browse: 1022 | Download: 1694
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Received |
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2018-06-26 00:34 |
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Peer-Review Started |
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2018-06-26 00:51 |
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To Make the First Decision |
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2018-07-19 07:49 |
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Return for Revision |
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2018-07-23 07:05 |
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Revised |
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2018-10-11 09:08 |
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Second Decision |
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2018-11-01 02:27 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-11-03 03:04 |
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Articles in Press |
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2018-11-03 03:04 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-11-10 22:09 |
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Typeset the Manuscript |
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2018-12-04 08:03 |
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Publish the Manuscript Online |
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2018-12-14 01:19 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Pathological changes in the cellular structures of retina and choroidea in the early stages of alloxan-induced diabetes
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Irina Danilova, Svetlana Medvedeva, Svetlana Shmakova, Margarita Chereshneva, Alexey Sarapultsev and Petr Sarapultsev |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Russian Science Foundation |
16-15-00039 |
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| Corresponding Author |
Alexey Sarapultsev, MD, PhD, Senior Researcher, Laboratory of Immunophatophysiology, Institute of Immunology and Physiology, Ural Division of Russian Academy of Sciences, 106 Pervomayskaya Street, Ekaterinburg 620049, Russia. a.sarapultsev@gmail.com |
| Key Words |
Alloxan; Diabetes; Diabetic retinopathy; Early stage; Morphology; Histological changes |
| Core Tip |
Diabetic retinopathy is the most frequent microvascular complication of diabetes. However, most of therapeutic approaches being developed do not address the early and potentially reversible failure of retinal perfusion. Thus, we examined pathological changes in the cellular structures of retina and choroidea in the early stages of diabetes in laboratory animals. According to the obtained results, the starting point in the development of destructive changes involves the early reduction in the number of melanocytes of the choroidea and the destruction of the retinal pigment epithelium, accompanied by an inflammatory process, which may represent a potential therapeutic target. |
| Publish Date |
2018-12-14 01:19 |
| Citation |
Danilova I, Medvedeva S, Shmakova S, Chereshneva M, Sarapultsev A, Sarapultsev P. Pathological changes in the cellular structures of retina and choroidea in the early stages of alloxan-induced diabetes. World J Diabetes 2018; 9(12): 239-251 |
| URL |
https://www.wjgnet.com/1948-9358/full/v9/i12/239.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v9.i12.239 |
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