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Articles Published Processes
11/21/2018 4:08:59 AM | Browse: 890 | Download: 1212
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Received |
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2018-07-07 14:52 |
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Peer-Review Started |
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2018-07-09 00:31 |
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To Make the First Decision |
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2018-08-31 00:38 |
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Return for Revision |
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2018-08-31 02:26 |
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Revised |
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2018-09-27 04:47 |
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Second Decision |
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2018-10-15 08:41 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-10-15 18:23 |
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Articles in Press |
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2018-10-15 18:23 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-11-05 21:08 |
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Typeset the Manuscript |
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2018-11-15 01:01 |
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Publish the Manuscript Online |
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2018-11-21 04:08 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Wen-Yan Xu, Qiang-Sheng Hu, Yi Qin, Bo Zhang, Wen-Sheng Liu, Quan-Xing Ni, Jin Xu and Xian-Jun Yu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Science Fund for Distinguished Young Scholars of China |
81625016 |
| National Science Foundation of China |
81502031 and 81772555 |
| Shanghai Municipal Commission of Health and Family Planning Grant |
20154Y0090 |
| Youth Research Foundation of Shanghai Municipal Commission of Health and Family Planning |
Z0124Y074 |
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| Corresponding Author |
Xian-Jun Yu, MD, PhD, Professor, Surgeon, Surgical Oncologist, Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, No. 270 DongAn Road, Xuhui District, Shanghai 200032, China. yuxianjun@fudanpci.org |
| Key Words |
Pancreatic cancer; Zinc finger E-box binding homeobox-1; Sirtuin 3; Methyl-CpG binding domain protein 1; Glycolysis |
| Core Tip |
Recent studies have demonstrated the impact of aerobic glycolysis on oncogenesis, proliferation, progression, and metastasis of cancer cells. Zinc finger E-box binding homeobox-1 (ZEB1) is an important regulator of metastasis and progression of pancreatic cancer, but its role in aerobic glycolysis has seldom been discussed. Our results demonstrated that ZEB1 is an important regulator of aerobic glycolysis. It has been demonstrated that ZEB1 regulates aerobic glycolysis by suppression of sirtuin 3 via interaction with methyl-CpG binding domain protein 1. Our results shed light on novel aspects and targets for treatment of pancreatic cancer. |
| Publish Date |
2018-11-21 04:08 |
| Citation |
Xu WY, Hu QS, Qin Y, Zhang B, Liu WS, Ni QX, Xu J, Yu XJ. Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer. World J Gastroenterol 2018; 24(43): 4893-4905 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i43/4893.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i43.4893 |
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