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Articles Published Processes
11/7/2018 2:30:09 AM | Browse: 1090 | Download: 1626
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Received |
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2018-07-05 00:18 |
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Peer-Review Started |
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2018-07-05 02:19 |
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To Make the First Decision |
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2018-08-27 02:24 |
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Return for Revision |
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2018-08-28 02:58 |
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Revised |
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2018-09-04 06:44 |
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Second Decision |
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2018-09-13 08:57 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-10-05 23:24 |
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Articles in Press |
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2018-10-05 23:24 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-10-10 01:01 |
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Typeset the Manuscript |
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2018-11-06 03:51 |
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Publish the Manuscript Online |
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2018-11-07 02:30 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
Open-Access: This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Role of autophagy in tumorigenesis, metastasis, targeted therapy and drug resistance of hepatocellular carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yi-Gang Wang, Bin-Rong Wang and Fang Huang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of China |
81803069 |
| Natural Science Foundation of Zhejiang Province of China |
LY18C070002 |
| Natural Science Foundation of Zhejiang Province of China |
LY16H160056 |
| 521 Talent Project of Zhejiang Sci-Tech University |
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| Corresponding Author |
Yi-Gang Wang, PhD, Associate Professor, Xinyuan Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci-Tech University, No. 5, Road 2, Xiasha District, Hangzhou 310018, Zhejiang Province, China. wangyigang43@163.com |
| Key Words |
Autophagy; Drug resistance; Hepatocellular carcinoma; Tumorigenesis; Metastasis; Targeted therapy |
| Core Tip |
Liver cancer seriously threatens human health, due to its high recurrence rate and poor prognosis. Hepatocellular carcinoma is the most common type of primary liver cancer. Autophagy plays a dual role in cancer. Basic autophagy exerts a tumor suppression function by maintaining genomic stability in normal cells. When cancer occurs, activated autophagy benefits cancer cell survival and promotes cancer development. However, the mechanism and function of autophagy in human cancers, especially liver cancer, have not been clarified. We summarize the physiological function of autophagy and its role in tumorigenesis, metastasis, targeted therapy and drug-resistance in hepatocellular carcinoma. |
| Publish Date |
2018-11-07 02:30 |
| Citation |
Huang F, Wang BR, Wang YG. Role of autophagy in tumorigenesis, metastasis, targeted therapy and drug resistance of hepatocellular carcinoma. World J Gastroenterol 2018; 24(41): 4643-4651 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i41/4643.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i41.4643 |
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