Publication Name	World Journal of Methodology
Manuscript ID	40549
Country	Italy

Received	2018-06-29 01:53
Peer-Review Started	2018-06-30 07:23
To Make the First Decision	2018-07-19 07:50
Return for Revision	2018-07-23 07:47
Revised	2018-08-09 11:14
Second Decision	2018-08-22 07:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-08-26 19:18
Articles in Press	2018-08-26 19:18
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-09-19 09:46
Typeset the Manuscript	2018-10-10 01:50
Publish the Manuscript Online	2018-10-11 05:16

ISSN	2222-0682 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Medical Laboratory Technology
Manuscript Type	Minireviews
Article Title	Towards a better understanding of anesthesia emergence mechanisms: Research and clinical implications
Manuscript Source	Invited Manuscript
All Author List	Marco Cascella, Sabrina Bimonte and Maria Rosaria Muzio
ORCID	Author(s) ORCID Number Marco Cascella http://orcid.org/0000-0002-5236-3132 Sabrina Bimonte http://orcid.org/0000-0002-5408-9675 Maria Rosaria Muzio http://orcid.org/0000-0002-8172-2325
Funding Agency and Grant Number
Corresponding Author	Marco Cascella, MD, Academic Fellow, Professor, Division of Anesthesia and Pain Management, Department of Supportive Care, Istituto Nazionale Tumori “Fondazione G. Pascale” - IRCSS, Via Mariano Semmola, Naples 80100, Italy. m.cascella@istitutotumori.na.it
Key Words	Delirium; Anesthesia; Isoflurane; Propofol; Consciousness; Awareness; Electroencephalography
Core Tip	Emergence from general anesthesia is not simply the reverse process of induction. The exhaustive knowledge of its complex neurobiological mechanisms is mandatory for avoiding or limiting a large number of anesthesia complications including altered mental status, and emergency awareness. Moreover, in a fascinating translational perspective, the study on this topic could provide new insights into the processes involved in cortical arousal, offering significant data to the research on brain arousal. On the other hand, research on the sleep-wake regulatory network, and on alterations in arousal processes could provide interesting suggestions for the general anesthesia research.
Publish Date	2018-10-11 05:16
Citation	Cascella M, Bimonte S, Muzio MR. Towards a better understanding of anesthesia emergence mechanisms: Research and clinical implications. World J Methodol 2018; 8(2): 9-16
URL	http://www.wjgnet.com/2222-0682/full/v8/i2/9.htm
DOI	http://dx.doi.org/10.5662/wjm.v8.i2.9

Full Article (PDF)	WJM-8-9.pdf
Full Article (Word)	WJM-8-9.doc
Manuscript File	40549-Review.docx
Answering Reviewers	40549-Answering reviewers.pdf
Audio Core Tip	40549-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	40549-Conflict-of-interest statement.pdf
Copyright License Agreement	40549-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	40549-Language certificate.pdf
Peer-review Report	40549-Peer-review(s).pdf
Scientific Misconduct Check	40549-Scientific misconduct check.pdf
Scientific Editor Work List	40549-Scientific editor work list.pdf