Publication Name	World Journal of Medical Genetics
Manuscript ID	4056
Country	Japan

Received	2013-06-11 22:47
Peer-Review Started	2013-06-12 19:23
To Make the First Decision	2013-08-08 11:16
Return for Revision	2013-08-08 17:54
Revised	2013-08-29 22:12
Second Decision	2013-09-03 14:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-09-04 07:22
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-12-03 11:29
Publish the Manuscript Online	2013-12-16 13:25

ISSN	2220-3184 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cell Biology
Manuscript Type	Autobiography
Article Title	Inhibitor of HIF-α subunit expression suppresses hypoxia-induced dedifferentiation of human NSCLC into cancer stem cell-like cells
Manuscript Source	Invited Manuscript
All Author List	Miho Akimoto, Hideko Nagasawa, Hitoshi Hori, Yoshihiro Uto, Yoshio Honma and Keizo Takenaga
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Education, Culture, Sports, Science and Technology 18590280 Foundation for the Promotion of Cancer Research in Japan Japan Arteriosclerosis Research Foundation Shimane University “S-TAKUMI Medical Nanotechnology” Project
Corresponding Author	Keizo Takenaga, PhD, Associated professor, Department of Life Science, Shimane University Faculty of Medicine, 89-1 Enya, Izumo 693-8501, Japan. biokeizo@med.shimane-u.ac.jp
Key Words	Non-small cell lung cancer; Tumor microenvironment; Hypoxia; Hypoxia-inducible factor; Differentiation; Cancer stem cells; Hypoxia-inducible factor inhibitor
Core Tip	Hypoxia induces the de-differentiation of human non-small cell lung cancer cells into cancer stem cell-like cells, and TX-402, a small-molecule inhibitor of hypoxia-inducible factor (HIF)-1α and HIF-2α expression, suppresses this hypoxia-induced process and, importantly, the metastatic ability of the cells.
Publish Date	2013-12-16 13:25
Citation	Akimoto M, Nagasawa H, Hori H, Uto Y, Honma Y, Takenaga K. An inhibitor of HIF-α subunit expression suppresses hypoxia-induced dedifferentiation of human NSCLC into cancer stem cell-like cells. World J Med Genet 2013; 3(4): 41-54
URL	http://www.wjgnet.com/2220-3184/full/v3/i4/41.htm
DOI	http://dx.doi.org/10.5496/wjmg.v3.i4.41

Full Article (PDF)	WJMG-3-41.pdf
Full Article (Word)	WJMG-3-41.doc
Manuscript File	4056-Review.doc
Answering Reviewers	4056-Answering reviewers.pdf
Copyright License Agreement	4056-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4056-Language certification.pdf
Peer-review Report	4056-Peer review(s).pdf
Scientific Editor Work List	4056-Scientific editor work list.doc