Publication Name	World Journal of Gastroenterology
Manuscript ID	40578
Country	France

Received	2018-07-03 08:53
Peer-Review Started	2018-07-04 01:10
To Make the First Decision	2018-08-01 03:19
Return for Revision	2018-08-01 06:41
Revised	2018-08-31 14:32
Second Decision	2018-09-13 08:57
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-10-05 23:26
Articles in Press	2018-10-05 23:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-10-15 05:25
Publish the Manuscript Online	2018-10-26 11:38

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Dimensions of hepatocellular carcinoma phenotypic diversity
Manuscript Source	Invited Manuscript
All Author List	Romain Désert, Natalia Nieto and Orlando Musso
ORCID	Author(s) ORCID Number Romain Désert http://orcid.org/0000-0003-3787-3801 Natalia Nieto http://orcid.org/0000-0002-2706-0295 Orlando Musso http://orcid.org/0000-0001-8881-6925
Funding Agency and Grant Number	Funding Agency Grant Number INSERM United States Department of Defense Office of the Congressionally Directed Medical Research Programs Grant CA170172
Corresponding Author	Orlando Musso, MD, PhD, Senior Scientist, Institut NuMeCan, Université de Rennes 1, Institut national de la recherche agronomique (INRA), Institut national de la santé et de la recherche médicale (INSERM), rue Henri Le Guilloux, Rennes F-35000, - None -, France. orlando.musso@inserm.fr
Key Words	Liver metabolism; Liver zonation; Hepa­tocellular carcinoma classification; Wnt/β-catenin; TP53; Tumor microenvironment; Inflammation; Tu­mor immunity; Hepatocyte proliferation; Hepatocyte differentiation
Core Tip	Recent work revealed substantial steps toward a unifying molecular classification of human hepatocellular carcinomas. The expected translation of high-throughput assays to the clinical practice will further refine evidence-based patient management in terms of prognosis and response to treatment.
Publish Date	2018-10-26 11:38
Citation	Désert R, Nieto N, Musso O. Dimensions of hepatocellular carcinoma phenotypic diversity. World J Gastroenterol 2018; 24(40): 4536-4547
URL	http://www.wjgnet.com/1007-9327/full/v24/i40/4536.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i40.4536

Full Article (PDF)	WJG-24-4536.pdf
Full Article (Word)	WJG-24-4536.doc
Manuscript File	40578-Review.docx
Answering Reviewers	40578-Answering reviewers.pdf
Audio Core Tip	40578-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	40578-Conflict-of-interest statement.pdf
Copyright License Agreement	40578-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	40578-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	40578-Language certificate.pdf
Peer-review Report	40578-Peer-review(s).pdf
Scientific Misconduct Check	40578-Scientific misconduct check.pdf
Scientific Editor Work List	40578-Scientific editor work list.pdf