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Articles Published Processes
11/27/2018 1:56:41 PM | Browse: 856 | Download: 999
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Received |
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2018-07-10 03:11 |
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Peer-Review Started |
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2018-07-10 06:11 |
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To Make the First Decision |
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2018-08-21 01:16 |
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Return for Revision |
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2018-08-21 06:53 |
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Revised |
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2018-08-24 17:34 |
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Second Decision |
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2018-09-19 08:27 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2018-10-11 12:19 |
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Articles in Press |
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2018-10-11 12:19 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-11-26 08:53 |
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Publish the Manuscript Online |
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2018-11-27 13:56 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Research & Experimental Medicine |
| Manuscript Type |
Review |
| Article Title |
Bioengineered functional humanized livers: An emerging supportive modality to bridge the gap of organ transplantation for management of end-stage liver diseases
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Sandeep Kumar Vishwakarma, Chandrakala Lakkireddy, Avinash Bardia, Syed Ameer Basha Paspala, Chaturvedula Tripura, Md Aejaz Habeeb and Aleem Ahmed Khan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Aleem Ahmed Khan, PhD, Associate Professor, Central Laboratory for Stem Cell Research and Translational Medicine, Centre for Liver Research and Diagnostics, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad 500058, Telangana, India, Hyderabad 500058, Telangana, India. aleem_a_khan@rediffmail.com |
| Key Words |
Bioengineered liver; Omentum; Secondary organ; Transplantation; End stage liver diseases |
| Core Tip |
The concept of bioengineering functional humanized neo-organs relies on finding more appropriate immunologically tolerable transplantation site. We have experienced omentum as more appropriate ectopic site with excellent properties of angiogenesis, regeneration, fibrotic reconstruction, and immunological compatibility which together endorse vascularisation, promote tissue healing, and minimize rejection of foreign body. However, regeneration of liver tissue in omentum is still unknown. Despite the amazing breakthroughs in the bioengineered organs, there is much work left to do. The approach described herein harbours enormous potential to overcome the limitations of organ transplantation and may support failing liver through ectopic transplantation as secondary organ. |
| Publish Date |
2018-11-27 13:56 |
| Citation |
Vishwakarma SK, Lakkireddy C, Bardia A, Paspala SAB, Tripura C, Habeeb MA, Khan AA. Bioengineered functional humanized livers: An emerging supportive modality to bridge the gap of organ transplantation for management of end-stage liver diseases. World J Hepatol 2018; 10(11): 822-836 |
| URL |
http://www.wjgnet.com/1948-5182/full/v10/i11/822.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v10.i11.822 |
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