Publication Name	World Journal of Diabetes
Manuscript ID	40616
Country	Croatia

Received	2018-08-29 01:30
Peer-Review Started	2018-08-29 11:43
To Make the First Decision	2018-10-08 06:42
Return for Revision	2018-10-08 06:57
Revised	2018-11-20 03:06
Second Decision	2018-11-23 09:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-11-26 19:21
Articles in Press	2018-11-26 19:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-11-30 08:44
Publish the Manuscript Online	2018-12-14 01:19

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Treatment approach to type 2 diabetes: Past, present and future
Manuscript Source	Invited Manuscript
All Author List	Kristina Blaslov, Fran Stjepan Naranđa, Ivan Kruljac and Ivana Pavlić Renar
ORCID	Author(s) ORCID Number Kristina Blaslov http://orcid.org/0000-0002-9747-8742 Fran Stjepan Naranđa http://orcid.org/0000-0003-0689-4028 Ivan Kruljac http://orcid.org/0000-0003-0323-0154 Ivana Pavlić Renar http://orcid.org/0000-0003-3495-7153
Funding Agency and Grant Number
Corresponding Author	Kristina Blaslov, MD, PhD, Doctor, Doctor, Department of endocrinology, Diabetes and Metabolic Diseases Mladen Sekso, University Hospital Center Sestre Milosrdnice, Vinogradska cesta 29, Zagreb 10000, Croatia. kblaslov@gmail.com
Key Words	Type 2 diabetes mellitus; Physical activity; Hyperglycaemia; Insulin resistance; Hypoglycaemic agents
Core Tip	Core tip: Type 2 diabetes mellitus (DM) is a global burden disease and one of the leading all-cause mortality cau­ses due to cardiovascular (CV) comp­lications. The rapid raise in the understanding of its pathogenesis resulted in treatment approach options beyond insulin that also provide beneficial CV effect. We discuss this scientific pathological and pharmacological development through a comprehensive historical approach. The wide spectrum of therapeutic agents currently used in type 2 DM treatment result in a CV mortality reduction which is not exclusively in correlation with glucose-lowering potency but is linked to its mechanism of action.
Publish Date	2018-12-14 01:19
Citation	Blaslov K, Naranđa FS, Kruljac I, Pavlić Renar I. Treatment approach to type 2 diabetes: Past, present and future. World J Diabetes 2018; 9(12): 209-219
URL	https://www.wjgnet.com/1948-9358/full/v9/i12/209.htm
DOI	https://dx.doi.org/10.4239/wjd.v9.i12.209

Full Article (PDF)	WJD-9-209.pdf
Full Article (Word)	WJD-9-209.doc
Manuscript File	40616-Review.docx
Answering Reviewers	40616-Answering reviewers.pdf
Audio Core Tip	40616-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	40616-Conflict-of-interest statement.pdf
Copyright License Agreement	40616-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	40616-Language certificate.pdf
Peer-review Report	40616-Peer-review(s).pdf
Scientific Misconduct Check	40616-Scientific misconduct check.pdf
Scientific Editor Work List	40616-Scientific editor work list.pdf