Publication Name	World Journal of Gastroenterology
Manuscript ID	4063
Country	United States

Received	2013-06-13 08:57
Peer-Review Started	2013-06-13 09:38
To Make the First Decision	2013-07-05 18:24
Return for Revision	2013-07-15 10:36
Revised	2013-07-17 06:37
Second Decision	2013-08-06 13:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-08-06 23:07
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-08-30 09:51
Publish the Manuscript Online	2013-09-14 11:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Appendectomy and Clostridium difficile colitis: Relationships revealed by clinical observations and immunology
Manuscript Source	Invited Manuscript
All Author List	Nathan L Sanders, R Randal Bollinger, Ryan Lee, Steven Thomas and William Parker
Funding Agency and Grant Number
Corresponding Author	William Parker, PhD, Department of Surgery, Duke University Medical Center, 200 Trent Dr, Durham, NC 27710, United States. bparker@duke.edu
Key Words	Appendectomy; Clostridium difficile; Colitis; Diarrheal illness; Vermiform appendix
Core Tip	Although the function of the appendix has remained an enigma for centuries, recently emerging advances in the fields of immunology and gut microbiology have merged with observations made in the clinic to form a coherent picture. Although the appendix is apparently a safe-house for beneficial bacteria, it seems likely that this safe-house does not satisfactorily protect the microbiome from broad spectrum antibiotics. In this view, selection pressures which threatened the microbiome and likely drove the evolution of the appendix have been supplanted in post-industrial society by new threats to the microbiome that the human body is not adapted for.
Publish Date	2013-09-14 11:17
Citation	Sanders NL, Bollinger RR, Lee R, Thomas S, Parker W. Appendectomy and Clostridium difficile colitis: Relationships revealed by clinical observations and immunology. World J Gastroenterol 2013; 19(34): 5607-5614
URL	http://www.wjgnet.com/1007-9327/full/v19/i34/5607.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i34.5607

Full Article (PDF)	WJG-19-5607.pdf
Manuscript File	4063-Review.docx
Answering Reviewers	4063-Answering reviewers.pdf
Copyright License Agreement	4063-Copyright assignment.pdf
Peer-review Report	4063-Peer reviews.pdf
Scientific Editor Work List	4063-Scientific editor work list.doc