Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	4067
Country	Canada

Received	2013-06-13 09:13
Peer-Review Started	2013-06-13 09:43
To Make the First Decision	2013-06-24 10:22
Return for Revision	2013-07-04 15:57
Revised	2013-07-08 21:51
Second Decision	2013-07-18 17:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-07-19 02:31
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-09-22 18:16
Publish the Manuscript Online	2013-11-04 12:31

ISSN	2150-5349 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Non-dietary forms of treatment for adult celiac disease
Manuscript Source	Invited Manuscript
All Author List	Hugh James Freeman
Funding Agency and Grant Number
Corresponding Author	Hugh James Freeman, Professor, Department of Medicine (Gastroenterology), University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver, BC V6T 1W5, Canada. hugfree@shaw.ca
Key Words	Adult celiac disease; Gluten-free diet; Non-dietary treatment of celiac disease; Tight junction inhibition; Protease; Immunotherapy; Vaccination
Core Tip	Non-dietary forms of treatment for adult celiac disease are currently being evaluated and some have reached clinical trials. Some novel approaches being investigated include hydrolysis of gliadin peptides, inhibition of intestinal permeability, blockade of T lymphocytes and transglutaminase 2/human leukocyte antigen-DQ2 functions as well as induction of immune tolerance. Future evaluations will need to define effects on specific endpoints and ensure an improvement in symptoms, laboratory test results and, most important, mucosal inflammatory changes. Therapeutic trials with novel agents will be difficult from an ethical perspective as the current form of management with a gluten-free diet already provides an excellent result for most compliant patients with celiac disease. Finally, effects on other known superimposed diseases will need close evaluation (i.e., lymphoproliferative and other malignancies).
Publish Date	2013-11-04 12:31
Citation	Freeman HJ. Non-dietary forms of treatment for adult celiac disease. World J Gastrointest Phar-macol Ther 2013; 4(4): 108-112
URL	http://www.wjgnet.com/2150-5349/full/v4/i4/108.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v4.i4.108

Full Article (PDF)	WJGPT-4-108.pdf
Manuscript File	4067-Review.doc
Answering Reviewers	4067-Answering reviewers.pdf
Copyright License Agreement	4067-Copyright assignment.pdf
Peer-review Report	4067-Peer reviews.pdf
Scientific Editor Work List	4067-Scientific editor work list.doc