Publication Name	World Journal of Gastroenterology
Manuscript ID	40713
Country	Brazil

Received	2018-07-05 00:43
Peer-Review Started	2018-07-05 02:40
To Make the First Decision	2018-08-27 02:26
Return for Revision	2018-08-28 02:36
Revised	2018-10-08 01:06
Second Decision	2018-10-15 08:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-10-15 18:24
Articles in Press	2018-10-15 18:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-11-06 03:50
Publish the Manuscript Online	2018-11-07 02:30

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Damage-associated molecular patterns in inflammatory bowel disease: From biomarkers to therapeutic targets
Manuscript Source	Invited Manuscript
All Author List	Hayandra F Nanini, Claudio Bernardazzi, Fernando Castro and Heitor Siffert Pereira de Souza
ORCID	Author(s) ORCID Number Hayandra F Nanini http://orcid.org/0000-0001-6866-7619 Claudio Bernardazzi http://orcid.org/0000-0003-4774-902X Fernando Castro http://orcid.org/0000-0003-3141-9632 Heitor Siffert Pereira de Souza http://orcid.org/0000-0002-3647-7324
Funding Agency and Grant Number	Funding Agency Grant Number Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E26/202.781/2017 Conselho Nacional de Desenvolvimento Científico e Tecnológico 302401/2016-4
Corresponding Author	Heitor Siffert Pereira de Souza, MD, PhD, Associate Research Scientist, Full Professor, Serviço de Gastroenterologia and Laboratório Multidisciplinar de Pesquisa, Departamento de Clínica Médica, Hospital Universitário, Universidade Federal do Rio de Janeiro, Rua Prof. Rodolpho Paulo Rocco 255, Ilha do Fundão, Rio de Janeiro 21941-913, RJ, Brazil. hsouza@hucff.ufrj.br
Key Words	Damage-associated molecular patterns; Environmental factors; Epigenetics; Inflammatory bowel disease; Therapeutic targets
Core Tip	Damage-associated molecular patterns (DAMPs) are basically endogenous stress molecules expressed or released as a consequence of cell or tissue damage. The release of endogenous DAMPs precipitates a secondary inflammatory response in inflammatory bowel disease (IBD), which may determine a self-sustaining chronic inflammatory process. DAMPs amplify the inflammatory response driven by immune and non-immune cells and promote several pathologic changes, which may be as­sociated with specific disease phenotypes. Excessive or persistent DAMP-mediated signalling can result in epigenetic modifications, which may sustain chronic in­flammation and also characterize IBD phenotypes. Preli­minary studies targeting DAMPs have shown promising beneficial therapeutic effects both in human and ex­perimental IBD.
Publish Date	2018-11-07 02:30
Citation	Nanini HF, Bernardazzi C, Castro F, de Souza HSP. Damage-associated molecular patterns in inflammatory bowel disease: From biomarkers to therapeutic targets. World J Gastroenterol 2018; 24(41): 4622-4634
URL	http://www.wjgnet.com/1007-9327/full/v24/i41/4622.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i41.4622

Full Article (PDF)	WJG-24-4622.pdf
Manuscript File	40713-Review.docx
Answering Reviewers	40713-Answering reviewers.pdf
Audio Core Tip	40713-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	40713-Conflict-of-interest statement.pdf
Copyright License Agreement	40713-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	40713-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	40713-Language certificate.pdf
Peer-review Report	40713-Peer-review(s).pdf
Scientific Misconduct Check	40713-Scientific misconduct check.pdf
Scientific Editor Work List	40713-Scientific editor work list.pdf