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Articles Published Processes
11/26/2018 12:48:17 AM | Browse: 999 | Download: 2050
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Received |
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2018-07-09 01:16 |
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Peer-Review Started |
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2018-07-10 05:57 |
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First Decision by Editorial Office Director |
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2018-08-02 15:46 |
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Return for Revision |
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2018-08-03 06:23 |
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Revised |
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2018-09-02 00:24 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2018-09-19 08:31 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2018-10-11 12:30 |
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Articles in Press |
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2018-10-11 12:30 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-11-21 01:06 |
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Publish the Manuscript Online |
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2018-11-26 00:48 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Observational Study |
| Article Title |
Incidence and risk factors for potentially suboptimal serum concentrations of vancomycin during cardiac surgery
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Paolo Cotogni, Cristina Barbero and Mauro Rinaldi |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Public Health Program of Regione Piemonte (Italy) |
2472/DA2001 |
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| Corresponding Author |
Paolo Cotogni, MD, MSc, Adjunct Professor, Doctor, Doctor, Department of Anesthesia, Intensive Care and Emergency,, Molinette Hospital, University of Turin, C.so Bramante, 88/90, Turin 10126, Italy. paolo.cotogni@unito.it |
| Key Words |
Cardiopulmonary; Bypass; Surgical site infections; Vancomycin pharmacokinetics; Antibiotic therapy; Methicillin-resistant Staphylococcus aureus |
| Core Tip |
The aim of this study was to investigate the incidence and risk factors for vancomycin concentrations less than 10 mg/L during cardiac surgery. Over a 1-year period, 236 patients were enrolled, and a total of 1682 serum vancomycin concentrations were measured. A total of 48% of patients were found to have ≥ 1 sample with a vancomycin level < 10 mg/L. The maximum concentration and area under the concentration-time curve were significantly higher in patients with no vancomycin levels less than 10 mg/L (P < 0.001). The multivariate analysis identified female gender, body mass index > 25 kg/m2, and creatinine clearance above 70 mL/min as risk factors for vancomycin levels less than 10 mg/L. |
| Publish Date |
2018-11-26 00:48 |
| Citation |
Cotogni P, Barbero C, Rinaldi M. Incidence and risk factors for potentially suboptimal serum concentrations of vancomycin during cardiac surgery. World J Cardiol 2018; 10(11): 234-241 |
| URL |
http://www.wjgnet.com/1949-8462/full/v10/i11/234.htm |
| DOI |
http://dx.doi.org/10.4330/wjc.v10.i11.234 |
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