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11/7/2018 2:30:09 AM | Browse: 309 | Download: 287
Publication Name World Journal of Gastroenterology
Manuscript ID 40811
Country/Territory Denmark
2018-07-23 03:09
Peer-Review Started
2018-07-23 05:54
To Make the First Decision
2018-08-27 06:52
Return for Revision
2018-08-28 00:17
2018-10-12 10:07
Second Decision
2018-10-19 09:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-10-21 06:42
Articles in Press
2018-10-21 06:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-11-06 03:51
Publish the Manuscript Online
2018-11-07 02:30
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Typing of pancreatic cancer-associated fibroblasts identifies different subpopulations
Manuscript Source Invited Manuscript
All Author List Michael Friberg Bruun Nielsen, Michael Bau Mortensen and Sönke Detlefsen
Author(s) ORCID Number
Michael Friberg Bruun Nielsen http://orcid.org/0000-0003-3244-9438
Michael Bau Mortensen http://orcid.org/0000-0002-7270-5005
Sönke Detlefsen http://orcid.org/0000-0002-9466-2333
Funding Agency and Grant Number
Funding Agency Grant Number
Aase and Ejnar Danielsen's Foundation 10-001452
Brødrene Hartmann’s Foundation A28308
The Foundation of 17.12.1981 19024005
Karen S. Jensens Grant 27-A1433
University of Southern Denmark Faculty Scholarship
Odense University Hospital Free Research Fund 29-A1500, 22-A1133 and 49-A2379
Odense University Hospital Ph.D. stipend 1032
Odense Pancreas Center (OPAC)
Corresponding author Sönke Detlefsen, MD, PhD, Associate Professor, Department of Pathology, Odense University Hospital, University of Southern Denmark, J.B. Winsløws Vej 15, Odense C 5000, Denmark. sonke.detlefsen@rsyd.dk
Keywords Pancreatic cancer; Tumour stroma; Cancer-associated fibroblasts; Extracellular matrix; Subtyping; Immunohistochemistry
Core Tip Pancreatic cancer (PC) has a poor prognosis, which may partially be attributed to the abundant desmo­plastic stroma, produced by cancer-associated fibroblasts (CAFs). The exact role of CAFs in PC is currently unclear, as these cells exhibited stimulation of cancer cell pro­liferation in vitro, but depletion of these cells promoted cancer progression in animal models. In this study, using immunohistochemistry, immunofluorescence (IF), double-IF, and/or in situ hybridization, we identified different immune phenotypic subpopulations of CAFs in PC, which may, at least in part, explain the previously published, partly contradictory data on the role of CAFs in PC. Further studies are needed to elucidate whether certain CAF subpopulations in PC have different functional properties.
Publish Date 2018-11-07 02:30
Citation Nielsen MFB, Mortensen MB, Detlefsen S. Typing of pancreatic cancer-associated fibroblasts identifies different subpopulations. World J Gastroenterol 2018; 24(41): 4663-4678
Url http://www.wjgnet.com/1007-9327/full/v24/i41/4663.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i41.4663
Full Article (PDF) WJG-24-4663.pdf
Manuscript File 40811-Review.docx
Answering Reviewers 40811-Answering reviewers.pdf
Audio Core Tip 40811-Audio core tip.wma
Conflict-of-Interest Disclosure Form 40811-Conflict-of-interest statement.pdf
Copyright License Agreement 40811-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 40811-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 40811-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 40811-Language certificate.pdf
Supplementary Material 40811-Supplementary material.pdf
Peer-review Report 40811-Peer-review(s).pdf
Scientific Misconduct Check 40811-Scientific misconduct check.pdf
Scientific Editor Work List 40811-Scientific editor work list.pdf