Publication Name	World Journal of Gastroenterology
Manuscript ID	40811
Country	Denmark

Received	2018-07-23 03:09
Peer-Review Started	2018-07-23 05:54
To Make the First Decision	2018-08-27 06:52
Return for Revision	2018-08-28 00:17
Revised	2018-10-12 10:07
Second Decision	2018-10-19 09:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-10-21 06:42
Articles in Press	2018-10-21 06:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-11-06 03:51
Publish the Manuscript Online	2018-11-07 02:30

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Typing of pancreatic cancer-associated fibroblasts identifies different subpopulations
Manuscript Source	Invited Manuscript
All Author List	Michael Friberg Bruun Nielsen, Michael Bau Mortensen and Sönke Detlefsen
ORCID	Author(s) ORCID Number Michael Friberg Bruun Nielsen http://orcid.org/0000-0003-3244-9438 Michael Bau Mortensen http://orcid.org/0000-0002-7270-5005 Sönke Detlefsen http://orcid.org/0000-0002-9466-2333
Funding Agency and Grant Number	Funding Agency Grant Number Aase and Ejnar Danielsen's Foundation 10-001452 Brødrene Hartmann’s Foundation A28308 The Foundation of 17.12.1981 19024005 Karen S. Jensens Grant 27-A1433 University of Southern Denmark Faculty Scholarship Odense University Hospital Free Research Fund 29-A1500, 22-A1133 and 49-A2379 Odense University Hospital Ph.D. stipend 1032 Odense Pancreas Center (OPAC)
Corresponding Author	Sönke Detlefsen, MD, PhD, Associate Professor, Department of Pathology, Odense University Hospital, University of Southern Denmark, J.B. Winsløws Vej 15, Odense C 5000, Denmark. sonke.detlefsen@rsyd.dk
Key Words	Pancreatic cancer; Tumour stroma; Cancer-associated fibroblasts; Extracellular matrix; Subtyping; Immunohistochemistry
Core Tip	Pancreatic cancer (PC) has a poor prognosis, which may partially be attributed to the abundant desmo­plastic stroma, produced by cancer-associated fibroblasts (CAFs). The exact role of CAFs in PC is currently unclear, as these cells exhibited stimulation of cancer cell pro­liferation in vitro, but depletion of these cells promoted cancer progression in animal models. In this study, using immunohistochemistry, immunofluorescence (IF), double-IF, and/or in situ hybridization, we identified different immune phenotypic subpopulations of CAFs in PC, which may, at least in part, explain the previously published, partly contradictory data on the role of CAFs in PC. Further studies are needed to elucidate whether certain CAF subpopulations in PC have different functional properties.
Publish Date	2018-11-07 02:30
Citation	Nielsen MFB, Mortensen MB, Detlefsen S. Typing of pancreatic cancer-associated fibroblasts identifies different subpopulations. World J Gastroenterol 2018; 24(41): 4663-4678
URL	http://www.wjgnet.com/1007-9327/full/v24/i41/4663.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i41.4663

Full Article (PDF)	WJG-24-4663.pdf
Manuscript File	40811-Review.docx
Answering Reviewers	40811-Answering reviewers.pdf
Audio Core Tip	40811-Audio core tip.wma
Conflict-of-Interest Disclosure Form	40811-Conflict-of-interest statement.pdf
Copyright License Agreement	40811-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	40811-Grant application form(s).pdf
Institutional Review Board Approval Form or Document	40811-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	40811-Language certificate.pdf
Supplementary Material	40811-Supplementary material.pdf
Peer-review Report	40811-Peer-review(s).pdf
Scientific Misconduct Check	40811-Scientific misconduct check.pdf
Scientific Editor Work List	40811-Scientific editor work list.pdf