| ISSN |
2307-8960 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Case Control Study |
| Article Title |
Iron metabolism disorders in patients with hepatitis B-related liver diseases
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan-Hang Gao, Jing-Yun Wang, Pei-Yan Liu, Jing Sun, Xiao-Mei Wang, Rui-Hong Wu, Xiuting He, Zhengkun Tu, Chunguang Wang, Hong-Qin Xu and Jun-Qi Niu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Science and Technology Major Project |
2014ZX10002002 |
| National key research plan "precision medicine research" key project |
2017YFC0908103 |
| the National Natural Science Foundation of China |
81700534 |
| Program for JLU Science and Technology Innovative Research Team |
2017TD-08 |
|
| Corresponding Author |
Jun-Qi Niu, PhD, Professor, Department of Hepatology, First Hospital of Jilin University, No.71 Xinmin Street, Changchun 130021, Jilin Province, China. junqi_niu@163.com |
| Key Words |
Hepatocellular carcinoma; Hepcidin; Iron staining; Hepatitis B; Liver fibrogenesis |
| Core Tip |
The relationship between hepatitis B viruses (HBV) related chronic liver diseases and levels of com-ponents in iron metabolism and the corresponding impact on liver disease severity have not been clearly described. In our study, we found that significantly higher serum ferritin and lower serum hepcidin levels were detected in all groups of HBV-infected patients compared with healthy controls. Serum iron, total iron binding capacity, and ser¬um transferrin levels were significantly lower in patients with cirrhosis and hepatocellular carcinoma, whereas the hepcidin level was higher than that in chronic hepatitis B patients. In conclusion, iron metabolism disorders are present in patients with HBV-related liver diseases. The characteristics of iron metabolism disorders in different development stages of HBV-related liver diseases varied. |
| Publish Date |
2018-11-06 10:20 |
| Citation |
Gao YH, Wang JY, Liu PY, Sun J, Wang XM, Wu RH, He XT, Tu ZK, Wang CG, Xu HQ, Niu JQ. Iron metabolism disorders in patients with hepatitis B-related liver diseases. World J Clin Cases 2018; 6(13): 600-610 |
| URL |
http://www.wjgnet.com/2307-8960/full/v6/i13/600.htm |
| DOI |
http://dx.doi.org/10.12998/wjcc.v6.i13.600 |
