Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	4084
Country	United States

Received	2013-06-13 15:16
Peer-Review Started	2013-06-14 15:42
To Make the First Decision	2013-07-05 18:24
Return for Revision	2013-07-15 11:20
Revised	2013-08-09 23:18
Second Decision	2013-09-05 11:24
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-09-05 12:59
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-10-09 14:28
Publish the Manuscript Online	2013-11-04 12:31

ISSN	2150-5349 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Validation of methods to assess potential biomarkers in pediatric patients with esophageal eosinophilia
Manuscript Source	Invited Manuscript
All Author List	Jennifer M Colombo, Nancy A Neilan, Jennifer Verrill Schurman and Craig A Friesen
Funding Agency and Grant Number
Corresponding Author	Jennifer M Colombo, MD, Divisions of Gastroenterology, Children’s Mercy Hospital and Clinics, University of Missouri at Kansas City School of Medicine, 2401 Gillham Road, Kansas City, MO 64108, United States. jmcolombo@cmh.edu
Key Words	Eosinophilia; Immunohistochemical staining; Tryptase; Major basic protein; Subepithelial fibrosis
Core Tip	Esophageal mucosal eosinophilia challenges many clinicians and researchers. Biomarkers have been proposed to help clarify and better characterize eosinophil driven disease. This study provides validation of methods used previously to differentiate low eosinophil density from high eosinophil density. Eosinophilic major basic protein appears to be the best predictor for classification of eosinophilia at both extremes. This lays the ground work for future studies to examine varying degrees of eosinophilia using biomarkers.
Publish Date	2013-11-04 12:31
Citation	Colombo JM, Neilan NA, Schurman JV, Friesen CA. Validation of methods to assess potential biomarkers in pediatric patients with esophageal eosinophilia. World J Gastrointest Phar-macol Ther 2013; 4(4): 113-119
URL	http://www.wjgnet.com/2150-5349/full/v4/i4/113.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v4.i4.113

Full Article (PDF)	WJGPT-4-113.pdf
Manuscript File	4084-Review.docx
Answering Reviewers	4084-Answering reviewers.pdf
Copyright License Agreement	4084-Copyright assignment.pdf
Peer-review Report	4084-Peer reviews.pdf
Scientific Editor Work List	4084-Scientific editor work list.doc