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Articles Published Processes
1/23/2019 7:57:13 AM | Browse: 931 | Download: 1188
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Received |
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2018-07-13 00:44 |
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Peer-Review Started |
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2018-07-13 06:21 |
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To Make the First Decision |
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2018-08-03 00:27 |
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Return for Revision |
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2018-08-03 03:40 |
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Revised |
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2018-08-24 07:16 |
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Second Decision |
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2018-10-17 02:59 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-10-17 22:18 |
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Articles in Press |
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2018-10-17 22:18 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-10-31 19:28 |
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Typeset the Manuscript |
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2019-01-18 07:44 |
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Publish the Manuscript Online |
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2019-01-23 07:57 |
| ISSN |
2220-3141(online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Critical Care Medicine |
| Manuscript Type |
Editorial |
| Article Title |
Expiratory flow-limitation in mechanically ventilated patients: A risk for ventilator-induced lung injury?
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Antonia Koutsoukou and Matteo Pecchiari |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Antonia Koutsoukou, PhD, Professor, ICU, 1st Department of Respiratory Medicine, National and Kapodistrian University of Athens Medical School, "Sotiria" Hospital for Diseases of the Chest, 152 Mesogion Av, Athens 11527, Greece. koutsoukou@yahoo.gr |
| Key Words |
Expiratory flow-limitation; Mechanical ventilation; Ventilator-induced lung injury; Acute respiratory distress syndrome; Positive end-expiratory pressure; Intrinsic positive end-expiratory pressure |
| Core Tip |
Expiratory flow limitation (EFL), the inability of expiratory flow to increase despite increasing driving pressure, is a common unrecognized occurrence during mechanical ventilation in a variety of intensive care unit conditions. It implies cyclic compression/decompression of the airways, is associated with intrinsic positive end-expiratory pressure (PEEPi) and inhomogeneous filling, and is often concomitant with cyclic recruitment/derecruitment. In acute respiratory distress syndrome, this probably entails the development of abnormally high stresses potentially injurious for the lung. External PEEP abolishes EFL and decreases ventilation and intrinsic PEEP heterogeneity, improving gas exchange. Moreover, external PEEP prevents cyclic airway collapse/reopening, possibly protecting the parenchyma from low lung volume ventilator-induced lung injury. |
| Publish Date |
2019-01-23 07:57 |
| Citation |
Koutsoukou A, Pecchiari M. Expiratory flow-limitation in mechanically ventilated patients: A risk for ventilator-induced lung injury? World J Crit Care Med 2019; 8(1): 1-8 |
| URL |
https://www.wjgnet.com/2220-3141/full/v8/i1/1.htm |
| DOI |
https://dx.doi.org/10.5492/wjccm.v8.i1.1 |
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