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Articles Published Processes
11/7/2018 2:30:09 AM | Browse: 1296 | Download: 1601
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Received |
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2018-07-19 05:59 |
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Peer-Review Started |
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2018-07-19 06:48 |
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To Make the First Decision |
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2018-08-27 02:30 |
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Return for Revision |
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2018-08-28 01:33 |
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Revised |
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2018-09-28 09:05 |
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Second Decision |
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2018-10-15 08:45 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-10-15 18:21 |
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Articles in Press |
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2018-10-15 18:21 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-11-06 03:51 |
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Publish the Manuscript Online |
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2018-11-07 02:30 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Mucosal adhesion and anti-inflammatory effects of Lactobacillus rhamnosus GG in the human colonic mucosa: A proof-of-concept study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Cristiano Pagnini, Vito Domenico Corleto, Michela Martorelli, Claudio Lanini, Giancarlo D'Ambra, Emilio Di Giulio and Gianfranco Delle Fave |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Cristiano Pagnini, MD, PhD, Doctor, Doctor, Department of Gastroenterology and Digestive Endoscopy, S. Giovanni Addolorata Hospital, Via dell’ Amba Aradam 9, Rome 00184, Italy. cpagnini@hsangiovanni.roma.it |
| Key Words |
Lactobacillus rhamnosus GG; Ulcerative colitis; Probiotic; Adhesion; Cytokines |
| Core Tip |
Since probiotic utilization is often driven by unproven health claims, we intended to explore the feasibility and effectiveness of a safe and well-characterized probiotic bacterial species, the Lactobacillus rhamnosus GG (LGG), in ulcerative colitis (UC) patients, through a preclinical proof-of-concept study. We demonstrated for the first time effective mucosal colonization and the anti-inflammatory effect of LGG, both ex vivo and in vivo, by quantifying bacterial DNA and cytokine RNA expression directly at the mucosal site using genomic techniques. Further translational and clinical studies would confirm the utility and optimize the therapeutic administration of LGG in UC patients. |
| Publish Date |
2018-11-07 02:30 |
| Citation |
Pagnini C, Corleto VD, Martorelli M, Lanini C, D’Ambra G, Di Giulio E, Delle Fave G. Mucosal adhesion and anti-inflammatory effects of Lactobacillus rhamnosus GG in the human colonic mucosa: A proof-of-concept study. World J Gastroenterol 2018; 24(41): 4652-4662 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i41/4652.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i41.4652 |
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