Publication Name	World Journal of Gastroenterology
Manuscript ID	4095
Country	China

Received	2013-06-14 08:34
Peer-Review Started	2013-06-14 16:09
To Make the First Decision	2013-07-05 18:25
Return for Revision	2013-07-22 15:33
Revised	2013-07-23 23:13
Second Decision	2013-08-06 14:09
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-08-06 23:10
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-08-27 14:15
Typeset the Manuscript	2013-09-21 18:07
Publish the Manuscript Online	2013-10-18 17:02

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	Alteration in gene expression profile and oncogenicity of esophageal squamous cell carcinoma by RIZ1 upregulation
Manuscript Source	Invited Manuscript
All Author List	Shang-Wen Dong, Dong Li, Cong Xu, Pei Sun, Yuan-Guo Wang and Peng Zhang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81201945 Science Foundation of Tianjin Medical University 2011KY08 Doctoral Program of Higher Education Research Fund 20091202110009 Natural Science Foundation of Tianjin, China 10JCYBJC11300
Corresponding Author	Peng Zhang, Professor, Department of Cardiothoracic Surgery, Tianjin Medical University General Hospital, Tianjin Medical University, No. 22, Qixiangtai Road, Heping District, Tianjin 300070, China. zhang_peng6036@yeah.net
Key Words	Retinoblastoma protein-interacting zinc finger gene 1; Microarray; Nude mice; Esophageal squamous cell carcinoma cells
Core Tip	Retinoblastoma protein-interacting zinc finger gene 1 (RIZ1) transfection induced widespread changes in gene expression profile of cell line TE13, with 960 genes upregulated and 1163 downregulated. Most of the differentially expressed genes are associated with cell development, supervision of viral replication, lymphocyte costimulatory, and immune system development in esophageal cells. RIZ1 gene may be involved in multiple cancer pathways, such as cytokine receptor interaction and transforming growth factor beta signaling. Virus infection may also be an important factor in the development of esophageal cancer.
Publish Date	2013-10-18 17:02
Citation	Dong SW, Li D, Xu C, Sun P, Wang YG, Zhang P. Alteration in gene expression profile and oncogenicity of esophageal squamous cell carcinoma by RIZ1 upregulation. World J Gastroenterol 2013; 19(37): 6170-6177
URL	http://www.wjgnet.com/1007-9327/full/v19/i37/6170.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i37.6170

Full Article (PDF)	WJG-19-6170.pdf
Manuscript File	4095-Review.doc
Answering Reviewers	4095-Answering reviewers.pdf
Copyright License Agreement	4095-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4095-Language certificate.pdf
Peer-review Report	4095-Peer reviews.pdf
Scientific Editor Work List	4095-Scientific editor work list.doc