Publication Name	World Journal of Gastroenterology
Manuscript ID	40962
Country	Japan

Received	2018-07-17 01:31
Peer-Review Started	2018-07-17 01:47
To Make the First Decision	2018-08-01 03:20
Return for Revision	2018-08-01 07:22
Revised	2018-08-02 10:10
Second Decision	2018-08-20 07:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-08-24 09:07
Articles in Press	2018-08-24 09:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-09-19 06:28
Publish the Manuscript Online	2018-09-20 02:33

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Serum anti-Helicobacter pylori antibody titer and its association with gastric nodularity, atrophy, and age: A cross-sectional study
Manuscript Source	Unsolicited Manuscript
All Author List	Osamu Toyoshima, Toshihiro Nishizawa, Kosuke Sakitani, Tadahiro Yamakawa, Yoshiyuki Takahashi, Nobutake Yamamichi, Keisuke Hata, Yasuyuki Seto, Kazuhiko Koike, Hidenobu Watanabe and Hidekazu Suzuki
ORCID	Author(s) ORCID Number Osamu Toyoshima http://orcid.org/0000-0002-6953-6079 Toshihiro Nishizawa http://orcid.org/0000-0003-4876-3384 Kosuke Sakitani http://orcid.org/0000-0002-4537-6023 Tadahiro Yamakawa http://orcid.org/0000-0002-7352-6375 Yoshiyuki Takahashi http://orcid.org/0000-0002-6724-8057 Nobutake Yamamichi http://orcid.org/0000-0002-5741-9887 Keisuke Hata http://orcid.org/0000-0003-4064-8701 Yasuyuki Seto http://orcid.org/0000-0002-6953-8752 Kazuhiko Koike http://orcid.org/0000-0002-9739-9243 Hidenobu Watanabe http://orcid.org/0000-0002-7871-4738 Hidekazu Suzuki http://orcid.org/0000-0002-3855-3140
Funding Agency and Grant Number
Corresponding Author	Osamu Toyoshima, MD, Doctor, Department of Gastroenterology, Toyoshima Endoscopy Clinic, 6-17-5 Seijo, Setagaya-ku, Tokyo 1570066, Japan. t@ichou.com
Key Words	Antibody; Helicobacter pylori; Gastritis; Gastric cancer; Endoscopy
Core Tip	A positive-low serum anti-Helicobacter pylori (H. pylori) antibody titer (E-plate Eiken) (10-49.9 U/mL) and a negative-high titer (3-9.9 U/mL) are associated with intestinal-type gastric cancer. A positive-high titer (≥ 50 U/mL) correlates with diffuse-type gastric cancer. Few studies have reported on the relationship between the serum antibody titer and endoscopic findings. In H. pylori-infected patients, a high titer of serum antibody was associated with gastric nodularity and atrophy. In H. pylori-infected patients, the antibody titer decreased in patients aged 60 years. Intestinal metaplasia and gastric atrophy were related to age ≥ 60 years in patients with positive titers.
Publish Date	2018-09-20 02:33
Citation	Toyoshima O, Nishizawa T, Sakitani K, Yamakawa T, Takahashi Y, Yamamichi N, Hata K, Seto Y, Koike K, Watanabe H, Suzuki H. Serum anti-Helicobacter pylori antibody titer and its association with gastric nodularity, atrophy, and age: A cross-sectional study. World J Gastroenterol 2018; 24(35): 4061-4068
URL	http://www.wjgnet.com/1007-9327/full/v24/i35/4061.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i35.4061

Full Article (PDF)	WJG-24-4061.pdf
Manuscript File	40962-Review.docx
Answering Reviewers	40962-Answering reviewers.pdf
Audio Core Tip	40962-Audio core tip.mp3
Biostatistics Review Certificate	40962-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	40962-Conflict-of-interest statement.pdf
Copyright License Agreement	40962-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	40962-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	40962-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	40962-Language certificate.pdf
Peer-review Report	40962-Peer-review(s).pdf
Scientific Misconduct Check	40962-Scientific misconduct check.pdf
Scientific Editor Work List	40962-Scientific editor work list.pdf