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Articles Published Processes
2/26/2019 3:18:49 AM | Browse: 918 | Download: 1166
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Received |
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2018-07-24 02:18 |
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Peer-Review Started |
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2018-07-24 05:59 |
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To Make the First Decision |
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2018-10-08 07:32 |
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Return for Revision |
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2018-10-10 01:15 |
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Revised |
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2018-12-11 11:02 |
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Second Decision |
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2018-12-29 01:45 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-01-01 17:06 |
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Articles in Press |
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2019-01-01 17:06 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-01-22 18:19 |
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Typeset the Manuscript |
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2019-02-25 10:20 |
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Publish the Manuscript Online |
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2019-02-26 03:18 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Anti-inflammatory potential of human corneal stroma-derived stem cells determined by a novel in vitro corneal epithelial injury model
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mariana Lizeth Orozco Morales, Nagi M Marsit, Owen D McIntosh, Andrew Hopkinson and Laura E Sidney |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Laura E Sidney, MSc, PhD, Senior Research Fellow, Academic Ophthalmology, Division of Clinical Neuroscience, University of Nottingham, Queen’s Medical Centre Campus, Nottingham NG7 2UH, United Kingdom. laura.sidney@nottingham.ac.uk |
| Key Words |
Cornea; Corneal injuries; Injury model; Corneal epithelium; Corneal stroma-derived stem cells; Amnion; Anti-inflammatory; Cell therapy |
| Core Tip |
We designed a novel in vitro inflammation model of the human corneal surface using human corneal epithelial cells treated with 20% (v/v) ethanol, followed by stimulation with 1 ng/mL interleukin-1β. We then used this model to demonstrate the anti-inflammatory and regenerative healing properties of human cornea stroma-derived stem cells seeded on an amniotic membrane substrate, in a co-culture model. This study is the first step in building a topical regenerative therapy for the treatment of inflammatory disorders of the front of the eye. |
| Publish Date |
2019-02-26 03:18 |
| Citation |
Orozco Morales ML, Marsit NM, McIntosh OD, Hopkinson A, Sidney LE. Anti-inflammatory potential of human corneal stroma-derived stem cells determined by a novel in vitro corneal epithelial injury model. World J Stem Cells 2019; 11(2): 84-99 |
| URL |
https://www.wjgnet.com/1948-0210/full/v11/i2/84.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v11.i2.84 |
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