Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	40969
Country	Canada

Received	2018-07-17 02:13
Peer-Review Started	2018-07-17 06:34
First Decision by Editorial Office Director	2018-08-08 17:43
Return for Revision	2018-08-13 01:39
Revised	2018-08-13 13:19
Publication Fee Transferred
Second Decision by Editor	2018-08-27 09:56
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2018-08-28 04:14
Articles in Press	2018-08-28 04:14
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-09-13 07:09
Publish the Manuscript Online	2018-09-15 11:10

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Editorial
Article Title	Immune blockade inhibitors and the radiation abscopal effect in gastrointestinal cancers
Manuscript Source	Invited Manuscript
All Author List	Ioannis A Voutsadakis
ORCID	Author(s) ORCID Number Ioannis A Voutsadakis http://orcid.org/0000-0002-93015951
Funding Agency and Grant Number
Corresponding Author	Ioannis A Voutsadakis, MD, PhD, Doctor, Doctor, Algoma District Cancer Program, Sault Area Hospital, 750 Great Northern Road, Sault Ste. Marie , ON P6B 0A8, Canada. ivoutsadakis@yahoo.com
Key Words	Abscopal effect; Radiation; CD28/cytotoxic T-lymphocyte antigen-4; Immune blockade inhibitors; Programmed death 1; Programmed death ligand-1
Core Tip	Immune checkpoint inhibitors activate the immune response to tumors by blocking inhibitory receptor pairs. Radiation treatment may also promote anti-tumor immune response. Thus, there exist an opportunity for synergy between the two treatment modalities that may be exploited therapeutically in gastrointestinal and other cancers.
Publish Date	2018-09-15 11:10
Citation	Voutsadakis IA. Immune blockade inhibitors and the radiation abscopal effect in gastrointestinal cancers. World J Gastrointest Oncol 2018; 10(9): 221-227
URL	http://www.wjgnet.com/1948-5204/full/v10/i9/221.htm
DOI	http://dx.doi.org/10.4251/wjgo.v10.i9.221

Full Article (PDF)	WJGO-10-221.pdf
Full Article (Word)	WJGO-10-221.doc
Manuscript File	40969-Review.docx
Answering Reviewers	40969-Answering reviewers.pdf
Audio Core Tip	40969-Audio core tip.wma
Conflict-of-Interest Disclosure Form	40969-Conflict-of-interest statement.pdf
Copyright License Agreement	40969-Copyright license agreement.pdf
Peer-review Report	40969-Peer-review(s).pdf
Scientific Misconduct Check	40969-Scientific misconduct check.pdf
Scientific Editor Work List	40969-Scientific editor work list.pdf