Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	40971
Country	South Korea

Received	2018-07-17 02:19
Peer-Review Started	2018-07-17 06:32
To Make the First Decision	2018-08-09 00:40
Return for Revision	2018-08-13 01:47
Revised	2018-08-16 07:09
Second Decision	2018-08-27 09:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-08-28 03:58
Articles in Press	2018-08-28 03:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-10-11 07:27
Publish the Manuscript Online	2018-10-15 12:09

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Editorial
Article Title	Inhibiting focal adhesion kinase: A potential target for enhancing therapeutic efficacy in colorectal cancer therapy
Manuscript Source	Invited Manuscript
All Author List	Keun-Yeong Jeong
ORCID	Author(s) ORCID Number Keun-Yeong Jeong http://orcid.org/0000-0002-4933-3493
Funding Agency and Grant Number
Corresponding Author	Keun-Yeong Jeong, PhD, Division of Research and Development, Metimedi Pharmaceuticals, R and D Division, Metimedi Pharmaceuticals Co., 263, Central-ro, Yeonsu-Gu, Incheon 22006, South Korea. alvirus@naver.com
Key Words	Colorectal cancer; Focal adhesion kinase; Focal adhesion kinase inhibitor; Anticancer effect
Core Tip	Despite ongoing development in treatment for colorectal cancer (CRC), effective markers for treatment of CRC have not been elucidated. FAK association with various kinases for progression and invasion of CRC has re­cently gained attention. The possibility for this associa­tion is accounted that FAK is interactions with integrins, growth factor receptors, and adjacent kinase domain. Targeting FAK is possible to explain the mechanism at the upstream level by which can mediate the expres­sion of various survival signaling and inhibition of onco-suppressor genes as well as inducing migration and invasion of the CRC cells. Therefore, FAK could be a pro­gnostic marker and a potential candidate target for CRC therapies.
Publish Date	2018-10-15 12:09
Citation	Jeong KY. Inhibiting focal adhesion kinase: A potential target for enhancing therapeutic efficacy in colorectal cancer therapy. World J Gastrointest Oncol 2018; 10(10): 290-292
URL	http://www.wjgnet.com/1948-5204/full/v10/i10/290.htm
DOI	http://dx.doi.org/10.4251/wjgo.v10.i10.290

Full Article (PDF)	WJGO-10-290.pdf
Full Article (Word)	WJGO-10-290.doc
Manuscript File	40971-Review.docx
Answering Reviewers	40971-Answering reviewers.pdf
Audio Core Tip	40971-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	40971-Conflict-of-interest statement.pdf
Copyright License Agreement	40971-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	40971-Language certificate.pdf
Peer-review Report	40971-Peer-review(s).pdf
Scientific Misconduct Check	40971-Scientific misconduct check.pdf
Scientific Editor Work List	40971-Scientific editor work list.pdf