Publication Name	World Journal of Gastroenterology
Manuscript ID	4099
Country	China

Received	2013-06-14 08:59
Peer-Review Started	2013-06-16 10:08
First Decision by Editorial Office Director
Return for Revision	2013-07-14 21:10
Revised	2013-09-27 13:38
Publication Fee Transferred
Second Decision by Editor	2013-11-05 11:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-11-05 12:27
Articles in Press	2014-06-06 11:07
Edit the Manuscript by Language Editor	2014-04-06 10:19
Typeset the Manuscript	2014-05-19 14:02
Publish the Manuscript Online	2014-06-06 16:55

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Physiology
Manuscript Type	Autobiography
Article Title	Investigation of cholecystokinin receptors in the human lower esophageal sphincter
Manuscript Source	Invited Manuscript
All Author List	Jun-Feng Liu, Jian Zhang, Xin-Bo Liu and Paul A Drew
Funding Agency and Grant Number	Funding Agency Grant Number Government Foundation Grant from Hebei Provincial Department of Education HBGX2005-52 National Natural Science Foundation of China 30371413
Corresponding Author	Jun-Feng Liu, PhD, Professor, Department of Thoracic Surgery, Fourth Hospital, Hebei Medical University, 12 Jiankang Road, Shijiazhuang 050011, Hebei Province, China. liujf@heinfo.net
Key Words	Cholecystokinins; Cholecystokinins-A receptor; Cholecystokinins-B receptor; Radioligand binding; Lower esophageal sphincter; Sling fibers; Clasp fibers
Core Tip	We isolated the sling and clasp muscles which help form the human lower esophageal sphincter. The expression of cholecystokinin (CCK)-A and CCK-B receptors was measured in the two muscles. The binding of 3H-CCK-8S to the CCK receptors was studied to determine the binding characteristics of the hormone to the receptor subtypes. It is concluded that the CCK-A receptor probably plays a more important role than the CCK-B receptor in mediating the contractile function of lower esophageal sphincter, through a combination of more receptors and a stronger binding affinity.
Publish Date	2014-06-06 16:55
Citation	Liu JF, Zhang J, Liu XB, Drew PA. Investigation of cholecystokinin receptors in the human lower esophageal sphincter. World J Gastroenterol 2014; 20(21): 6554-6559
URL	http://www.wjgnet.com/1007-9327/full/v20/i21/6554.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i21.6554

Full Article (PDF)	WJG-20-6554.pdf
Full Article (Word)	WJG-20-6554.doc
Manuscript File	4099-Review.doc
Answering Reviewers	4099-Answering reviewers.pdf
Copyright License Agreement	4099-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4099-Language certificate.pdf
Peer-review Report	4099-Peer reviews.pdf
Scientific Editor Work List	4099-Scientific editor work list.doc