BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
11/14/2018 1:33:49 AM | Browse: 774 | Download: 1010
Publication Name World Journal of Diabetes
Manuscript ID 41008
Country/Territory United States
Received
2018-07-19 02:20
Peer-Review Started
2018-07-19 12:59
To Make the First Decision
2018-08-09 00:41
Return for Revision
2018-08-13 01:52
Revised
2018-10-08 02:34
Second Decision
2018-10-23 03:34
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-10-24 00:18
Articles in Press
2018-10-24 00:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-11-09 02:58
Publish the Manuscript Online
2018-11-14 01:33
ISSN 1948-9358 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Endocrinology & Metabolism
Manuscript Type Field of Vision
Article Title Circadian rhythms of hormone secretion and obesity
Manuscript Source Invited Manuscript
All Author List Rajendra Raghow
ORCID
Author(s) ORCID Number
Rajendra Raghow http://orcid.org/0000-0002-4709-7669
Funding Agency and Grant Number
Corresponding Author Rajendra Raghow, PhD, Professor, Department of Veterans Affairs Medical Center, 1030 Jefferson Avenue, Memphis, TN 38104, United States. rraghow@uthsc.edu
Key Words Circadian rhythms; Glucocorticoids; Adipose tissue; Pre-adipocytes; Stem cells; Terminal differentiation
Core Tip Bahrami-Nejad et al examined pre-adipocytes for their ability to differentiate into fat cells in response to hormonal stimuli that were presented either in a pulsatile manner, mimicking circadian rhythms, or de­livered continuously. These experiments revealed that adipocyte differentiation program, made up of slow and fast feedback circuits, was able to distinguish between the oscillating and continuous hormonal signals. The authors showed that pre-adipocytes apparently used the fast, positive feedback network to reject the oscillating hormonal cues. In contrast, if delivered continuously, similar strength glucocorticoids impinged on the slow positive feedback circuit to trigger maximal differentia­tion of pre-adipocytes into bone fide fat cells. The pulsatile vs continuous hormone stimuli were similarly discriminated in vivo since mice receiving glucocorticoids in a non-oscillating manner for 21 d elicited increased accumulation of subcutaneous and visceral fat. These data elucidate a potential mechanism underling the development of obesity associated with chronic stress or Cushing’s disease.
Publish Date 2018-11-14 01:33
Citation Raghow R. Circadian rhythms of hormone secretion and obesity. World J Diabetes 2018; 9(11): 195-198
URL http://www.wjgnet.com/1948-9358/full/v9/i11/195.htm
DOI http://dx.doi.org/10.4239/wjd.v9.i11.195
Full Article (PDF) WJD-9-195.pdf
Full Article (Word) WJD-9-195.doc
Manuscript File 41008-Review.docx
Answering Reviewers 41008-Answering reviewers.pdf
Audio Core Tip 41008-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 41008-Conflict-of-interest statement.pdf
Copyright License Agreement 41008-Copyright license agreement.pdf
Peer-review Report 41008-Peer-review(s).pdf
Scientific Misconduct Check 41008-Scientific misconduct check.pdf
Scientific Editor Work List 41008-Scientific editor work list.pdf