| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Autobiography |
| Article Title |
Deletion of Gpr128 results in weight loss and increased intestinal contraction frequency
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Ying-Yin Ni, Yan Chen, Shun-Yuan Lu, Bi-Ying Sun, Fang Wang, Xiao-Lin Wu, Su-Ying Dang, Guo-Hua Zhang, Hong-Xin Zhang, Yin Kuang, Jian Fei, Ming-Min Gu, Wei-Fang Rong and Zhu-Gang Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shanghai Municipal Health Bureau Foundation |
2010037 |
| National Natural Science Foundation of China |
30900156 |
| National Natural Science Foundation of China |
81071444 |
| National Natural Science Foundation of China |
31000986 |
|
| Corresponding Author |
Wei-Fang Rong, Professor, Director, Department of Physiology, Shanghai Jiaotong University School of Medicine, 280 South Chongqing Road, Shanghai 200025,China. weifangrong@shsmu.edu.cn
|
| Key Words |
G-protein-coupled receptors; Gpr128; Knockout mouse; Weight loss; Intestinal contraction frequency |
| Core Tip |
The Adhesion family is the second largest subfamily of the G-protein-coupled receptors (GPCR). The physiological function of the orphan Adhesion-GPCR Gpr128 is unknown. In the present study, we generated Gpr128 knockout mice and confirmed the selective expression of Gpr128 in the intestinal tissues. Phenotypic analysis revealed that targeted deletion of Gpr128 in the mouse resulted in reduced body weight gain and increased frequency of peristaltic contraction and slow wave potential in the small intestine. The physiological roles of Gpr128 in the gastrointestinal tract and its potential as a therapeutic target for obesity and nutritional disorders warrant further investigation.
|
| Publish Date |
2014-01-19 14:17 |
| Citation |
Ni YY, Chen Y, Lu SY, Sun BY, Wang F, Wu XL, Dang SY, Zhang GH, Zhang HX, Kuang Y, Fei J, Gu MM, Rong WF, Wang ZG. Deletion of Gpr128 results in weight loss and increased intestinal contraction frequency. World J Gastroenterol 2014; 20(2): 498-508 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i2/498.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i2.498 |
