Publication Name	World Journal of Gastroenterology
Manuscript ID	4110
Country	China

Received	2013-06-15 09:34
Peer-Review Started	2013-06-16 09:23
To Make the First Decision	2013-07-05 18:26
Return for Revision	2013-07-14 20:24
Revised	2013-07-29 20:59
Second Decision	2013-09-17 09:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-09-17 11:30
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-10-09 13:50
Typeset the Manuscript	2013-10-18 20:45
Publish the Manuscript Online	2013-11-13 08:37

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	Overexpression of nuclear β-catenin in rectal adenocarcinoma is associated with radioresistance
Manuscript Source	Invited Manuscript
All Author List	Lin Wang, Xiao-Mei Zhang, Zhen Li, Xi-Jun Liu, Jie Chai, Guang-Yong Zhang and Yu-Feng Cheng
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Shandong Province, China ZR2012HQ032 China Postdoctoral Science Foundation funded project 2013M531614
Corresponding Author	Yu-Feng Cheng, MD, Department of Radiation Oncology, Qilu Hospital, Shandong University, 107 Wenhua Xi Road, Jinan 250012, Shandong Province, China. 33943219@qq.com
Key Words	β-catenin; Rectal cancer; Preoperative radiotherapy; Radioresistance; Colorectal cancer
Core Tip	In this paper we investigated the relationship between overexpression of nuclear β-catenin in rectal adenocarcinoma and radioresistance. We first confirmed that nuclear β-catenin overexpression in rectal adenocarcinoma is associated with radioresistance. Most importantly, we found that nuclear β-catenin-based prediction achieved a 83% accuracy, 65% sensitivity and 88% specificity for radioresistance. We provided a novel possible molecular mechanism to explain the radioresistance in rectal adenocarcinoma and thus may provide a new therapeutic target for enhancing radiosensitivity.
Publish Date	2013-11-13 08:37
Citation	Wang L, Zhang XM, Li Z, Liu XJ, Chai J, Zhang GY, Cheng YF. Overexpression of nuclear β-catenin in rectal adenocarcinoma is associated with radioresistance. World J Gastroenterol 2013; 19(40): 6876-6882
URL	http://www.wjgnet.com/1007-9327/full/v19/i40/6876.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i40.6876

Full Article (PDF)	WJG-19-6876.pdf
Manuscript File	4110-Review.doc
Answering Reviewers	4110-Answering reviewers.pdf
Copyright License Agreement	4110-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4110-Language certificate.pdf
Peer-review Report	4110-Peer reviews.pdf
Scientific Editor Work List	4110-Scientific editor work list.doc