Publication Name	World Journal of Clinical Cases
Manuscript ID	41140
Country	China

Received	2018-07-31 02:01
Peer-Review Started	2018-07-31 09:23
To Make the First Decision	2018-08-21 01:45
Return for Revision	2018-08-22 01:33
Revised	2018-08-23 23:51
Second Decision	2018-08-28 10:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-08-28 14:51
Articles in Press	2018-08-28 14:51
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-09-06 03:34
Typeset the Manuscript	2018-10-31 07:08
Publish the Manuscript Online	2018-11-06 10:20

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Case Report
Article Title	Possible connection between elevated serum -fetoprotein and placental necrosis during pregnancy: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Meng-Yao Yu, Lei Xi, Jie-Xin Zhang and Shi-Chang Zhang
ORCID	Author(s) ORCID Number Meng-Yao Yu http://orcid.org/0000-0001-8707-355X Lei Xi http://orcid.org/0000-0003-2181-4970 Jie-Xin Zhang http://orcid.org/0000-0003-1407-7562 Shi-Chang Zhang http://orcid.org/0000-0002-6587-2518
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81501817 National Natural Science Foundation of China 81671836 Natural Science Youth Foundation of Jiangsu Province BK20151029 Key Laboratory for Laboratory Medicine of Jiangsu Province of China ZDXKB2016005
Corresponding Author	Shi-Chang Zhang, MD, PhD, Assistant Professor, Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Guangzhou Road 300, Nanjing 210029, Jiangsu Province, China. zsc78@yeah.net
Key Words	Serum α-fetoprotein; Intermittent bleeding; Necrosis; Gynecological sonography; Placenta previa
Core Tip	Placental necrosis with extremely high mater¬nal serum -fetoprotein (AFP) is rare. We reported a 23-year-old female patient with central placenta previa suffered from repeated vaginal bleeding. Follow-up ultrasonography revealed a gradually enlarging hypoecho between the amniotic sac and the uterine myometrium. Until 32 wk of gestation, laboratory results showed extremely elevated maternal serum AFP. Both intraoperative exploration of the placenta and histological examination demonstrated the hypoechoic area was necrotic tissue. To our knowledge, this is the first report of a rare case of extreme AFP level in placental necrosis. Clinicians should consider the combination usage of quantitative ultrasound imaging and AFP as a practical tool for assessing placental lesions.
Publish Date	2018-11-06 10:20
Citation	Yu MY, Xi L, Zhang JX, Zhang SC. Possible connection between elevated serum -fetoprotein and placental necrosis during pregnancy: A case report and review of literature. World J Clin Cases 2018; 6(13): 675-678
URL	http://www.wjgnet.com/2307-8960/full/v6/i13/675.htm
DOI	http://dx.doi.org/10.12998/wjcc.v6.i13.675

Full Article (PDF)	WJCC-6-675.pdf
Full Article (Word)	WJCC-6-675.doc
CARE Checklist–2016	41140-CARE checklist (2013).pdf
Manuscript File	41140-Review.doc
Answering Reviewers	41140-Answering reviewers.pdf
Audio Core Tip	41140-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	41140-Conflict-of-interest statement.pdf
Copyright License Agreement	41140-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	41140-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	41140-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	41140-Language certificate.pdf
Peer-review Report	41140-Peer-review(s).pdf
Scientific Misconduct Check	41140-Scientific misconduct check.pdf
Scientific Editor Work List	41140-Scientific editor work list.pdf