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Publication Name World Journal of Clinical Cases
Manuscript ID 4115
Country/Territory Italy
Received
2013-06-15 09:53
Peer-Review Started
2013-06-16 09:53
To Make the First Decision
2013-07-19 08:31
Return for Revision
2013-07-19 16:42
Revised
2013-08-08 19:55
Second Decision
2013-08-20 10:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-08-20 12:49
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-08-27 16:43
Publish the Manuscript Online
2013-09-11 10:40
ISSN 2307-8960 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Clinical Neurology
Manuscript Type Case Report
Article Title Dynamic mechanical allodynia following finger amputation: Unexpected skin hyperinnervation
Manuscript Source Invited Manuscript
All Author List Michelangelo Buonocore, Maria Concetta Gagliano and Cesare Bonezzi
Funding Agency and Grant Number
Corresponding author Michelangelo Buonocore, MD, Unit of Clinical Neurophysiology and Neurodiagnostic Skin Biopsy, “Salvatore Maugeri” Foundation, Scientific Institute of Pavia, Via Maugeri 10, 27100 Pavia, Italy. michelangelo.buonocore@fsm.it
Key Words Neuropathic pain; Hyperinnervation; Dynamic mechanical allodynia; Amputation; Skin biopsy
Core Tip In some patients with post-amputation chronic pain dynamic mechanical allodynia (a painful sensation evoked by gentle stroking the skin) represents the most disabling problem. So far, little is known about the mechanism of this peculiar type of pain. We present here a patient who complained of severe dynamic mechanical allodynia in the hand after amputation of the left second finger. The neurodiagnostic skin biopsy showed an increased innervation of the allodynic skin compared to the contralateral, normal skin area (+ 80.1%), suggesting hyperinnervation as a possible pain mechanism. Interestingly, topical capsaicin (0.075%) relieved allodynia for a long period.
Publish Date 2013-09-11 10:40
Citation Buonocore M, Gagliano MC, Bonezzi C. Dynamic mechanical allodynia following finger amputation: Unexpected skin hyperinnervation. World J Clin Cases 2013; 1(6): 197-201
Url http://www.wjgnet.com/2307-8960/full/v1/i6/197.htm
DOI http://dx.doi.org/10.12998/wjcc.v1.i6.197
Full Article (PDF) WJCC-1-197.pdf
Manuscript File 4115-Review.doc
Answering Reviewers 4115-Answering reviewers.pdf
Copyright License Agreement 4115-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 4115-Language certificate.pdf
Peer-review Report 4115-Peer reviews.pdf
Scientific Editor Work List 4115-Scientific editor work list.doc