Publication Name	World Journal of Clinical Cases
Manuscript ID	4115
Country	Italy

Received	2013-06-15 09:53
Peer-Review Started	2013-06-16 09:53
To Make the First Decision	2013-07-19 08:31
Return for Revision	2013-07-19 16:42
Revised	2013-08-08 19:55
Second Decision	2013-08-20 10:28
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-08-20 12:49
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-08-27 16:43
Publish the Manuscript Online	2013-09-11 10:40

ISSN	2307-8960 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Clinical Neurology
Manuscript Type	Case Report
Article Title	Dynamic mechanical allodynia following finger amputation: Unexpected skin hyperinnervation
Manuscript Source	Invited Manuscript
All Author List	Michelangelo Buonocore, Maria Concetta Gagliano and Cesare Bonezzi
Funding Agency and Grant Number
Corresponding Author	Michelangelo Buonocore, MD, Unit of Clinical Neurophysiology and Neurodiagnostic Skin Biopsy, “Salvatore Maugeri” Foundation, Scientific Institute of Pavia, Via Maugeri 10, 27100 Pavia, Italy. michelangelo.buonocore@fsm.it
Key Words	Neuropathic pain; Hyperinnervation; Dynamic mechanical allodynia; Amputation; Skin biopsy
Core Tip	In some patients with post-amputation chronic pain dynamic mechanical allodynia (a painful sensation evoked by gentle stroking the skin) represents the most disabling problem. So far, little is known about the mechanism of this peculiar type of pain. We present here a patient who complained of severe dynamic mechanical allodynia in the hand after amputation of the left second finger. The neurodiagnostic skin biopsy showed an increased innervation of the allodynic skin compared to the contralateral, normal skin area (+ 80.1%), suggesting hyperinnervation as a possible pain mechanism. Interestingly, topical capsaicin (0.075%) relieved allodynia for a long period.
Publish Date	2013-09-11 10:40
Citation	Buonocore M, Gagliano MC, Bonezzi C. Dynamic mechanical allodynia following finger amputation: Unexpected skin hyperinnervation. World J Clin Cases 2013; 1(6): 197-201
URL	http://www.wjgnet.com/2307-8960/full/v1/i6/197.htm
DOI	http://dx.doi.org/10.12998/wjcc.v1.i6.197

Full Article (PDF)	WJCC-1-197.pdf
Manuscript File	4115-Review.doc
Answering Reviewers	4115-Answering reviewers.pdf
Copyright License Agreement	4115-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4115-Language certificate.pdf
Peer-review Report	4115-Peer reviews.pdf
Scientific Editor Work List	4115-Scientific editor work list.doc