Publication Name	World Journal of Gastroenterology
Manuscript ID	41156
Country	Germany

Received	2018-08-01 01:06
Peer-Review Started	2018-08-01 01:19
First Decision by Editorial Office Director	2018-08-24 13:26
Return for Revision	2018-08-27 07:18
Revised	2018-09-20 09:38
Publication Fee Transferred
Second Decision by Editor	2018-09-27 06:19
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2018-10-05 23:05
Articles in Press	2018-10-05 23:05
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-10-10 01:53
Publish the Manuscript Online	2018-10-12 05:32

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Liver stiffness reversibly increases during pregnancy and independently predicts preeclampsia
Manuscript Source	Invited Manuscript
All Author List	Franziska J Ammon, Anna Kohlhaas, Omar Elshaarawy, Johannes Mueller, Thomas Bruckner, Christof Sohn, Gabriele Fluhr, Herbert Fluhr and Sebastian Mueller
ORCID	Author(s) ORCID Number Franziska J Ammon http://orcid.org/0000-0002-8877-9711 Anna Kohlhaas http://orcid.org/0000-0001-7677-1619 Omar Elshaarawy http://orcid.org/0000-0002-6945-6204 Johannes Mueller http://orcid.org/0000-0002-5205-4129 Thomas Bruckner http://orcid.org/0000-0001-9342-3456 Christof Sohn http://orcid.org/0000-0001-9430-4037 Gabriele Fluhr http://orcid.org/0000-0001-7415-2312 Herbert Fluhr http://orcid.org/0000-0001-9300-4868 Sebastian Mueller http://orcid.org/0000-0002-3577-8491
Funding Agency and Grant Number	Funding Agency Grant Number DFG MU 1373/9-1
Corresponding Author	Sebastian Mueller, MD, PhD, Professor, Department of Medicine and Center for Alcohol Research, Liver Disease and Nutrition, Salem Medical Center and Center for Alcohol Research and Liver Disease, University of Heidelberg, Zeppelinstraße 11–33, Heidelberg 69121, Germany. sebastian.mueller@urz.uni-heidelberg.de
Key Words	Pregnancy; Transient elastography; Liver stiffness; Pregnancy complications; Hemolysis, elevated liver enzymes and low platelets syndrome; Intrahepatic cholestasis of pregnancy; Preeclampsia
Core Tip	Liver stiffness (LS) was measured by transient elastography during pregnancy in 537 healthy pregnant women without complications and in 62 women with pregnancy complications such as preeclampsia or intrahepatic cholestasis of pregnancy. Our results show that LS increases during pregnancy to levels above 6 kPa even in women without pregnancy complications and rapidly normalizes within 24 h after delivery. LS was significantly elevated in women with preeclampsia and, moreover, an independent predictor for preeclampsia in multivariate analysis. In conclusion, LS could be a novel non-invasive screening parameter to identify pregnant women at risk for complications of pregnancy.
Publish Date	2018-10-12 05:32
Citation	Ammon FJ, Kohlhaas A, Elshaarawy O, Mueller J, Bruckner T, Sohn C, Fluhr G, Fluhr H, Mueller S. Liver stiffness reversibly increases during pregnancy and independently predicts preeclampsia. World J Gastroenterol 2018; 24(38): 4393-4402
URL	http://www.wjgnet.com/1007-9327/full/v24/i38/4393.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i38.4393

Full Article (PDF)	WJG-24-4393.pdf
STROBE Statement	41156-STROBE statement.pdf
Manuscript File	41156-Review.docx
Answering Reviewers	41156-Answering reviewers.pdf
Audio Core Tip	41156-Audio core tip.mp3
Biostatistics Review Certificate	41156-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	41156-Conflict-of-interest statement.pdf
Copyright License Agreement	41156-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	41156-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	41156-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	41156-Non-Native-Speakers-of-English-Editing-Certificate-revision.pdf
Supplementary Material	41156-Supplementary material.pdf
Peer-review Report	41156-Peer-review(s).pdf
Scientific Misconduct Check	41156-Scientific misconduct check.pdf
Scientific Editor Work List	41156-Scientific editor work list.pdf