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11/21/2018 4:08:59 AM | Browse: 918 | Download: 988
Publication Name World Journal of Gastroenterology
Manuscript ID 41169
Country/Territory Germany
Received
2018-08-03 00:45
Peer-Review Started
2018-08-03 05:17
To Make the First Decision
2018-10-08 03:46
Return for Revision
2018-10-08 07:57
Revised
2018-10-22 16:08
Second Decision
2018-11-02 09:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-11-02 17:02
Articles in Press
2018-11-02 17:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-11-10 05:21
Publish the Manuscript Online
2018-11-21 04:08
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Establishment, functional and genetic characterization of three novel patient-derived rectal cancer cell lines
Manuscript Source Invited Manuscript
All Author List Michael Gock, Christina S Mullins, Carina Bergner, Friedrich Prall, Robert Ramer, Anja Goeder, Oliver H Krämer, Falko Lange, Bernd J Krause, Ernst Klar and Michael Linnebacher
ORCID
Author(s) ORCID Number
Michael Gock http://orcid.org/0000-0001-6393-1097
Christina S Mullins http://orcid.org/0000-0003-2296-2027
Carina Bergner http://orcid.org/0000-0001-7346-8067
Friedrich Prall http://orcid.org/0000-0001-8103-5544
Robert Ramer http://orcid.org/0000-0003-1778-8829
Anja Goeder http://orcid.org/0000-0001-9743-1656
Oliver H Krämer http://orcid.org/0000-0003-3973-045X
Falko Lange http://orcid.org/0000-0001-8782-5205
Bernd J Krause http://orcid.org/0000-0002-2572-4131
Ernst Klar http://orcid.org/0000-0002-1159-5797
Michael Linnebacher http://orcid.org/0000-0001-8054-1402
Funding Agency and Grant Number
Corresponding Author Michael Linnebacher, PhD, Postdoc, Research Scientist, Section of Molecular Oncology and Immunotherapy, University Medical Center, Schillingallee 35, Rostock 18055, Germany. michael.linnebacher@med.uni-rostock.de
Key Words Patient-derived tumor model; Rectal cancer; 18F-fluorodesoxyglucose; 18F-fluorothymidine; FOLFOX; FOLFIRI; Personalized medicine
Core Tip Ultra-low passage and in-depth characterized tumor models are highly desirable for basic research and assessment of individual response prediction to current or novel therapy regimens. Here, for the first time, we describe three patient-derived rectal cancer cell lines established either directly from patient’s tumor samples or after xenografting. These tumor models were characterized according to phenotype, molecular-, as well as growth and morphological features and sensitivity to chemotherapeutic drugs and radiation, including radiochemotherapy. In addition, glucose metabolism was assessed with 18F-fluorodeoxyglucose and proliferation with 18F-fluorothymidine. These cell lines provide excellent tools for basic and translational research of rectal cancers’ biological characteristics.
Publish Date 2018-11-21 04:08
Citation Gock M, Mullins CS, Bergner C, Prall F, Ramer R, Göder A, Krämer OH, Lange F, Krause BJ, Klar E, Linnebacher M. Establishment, functional and genetic characterization of three novel patient-derived rectal cancer cell lines. World J Gastroenterol 2018; 24(43): 4880-4892
URL http://www.wjgnet.com/1007-9327/full/v24/i43/4880.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i43.4880
Full Article (PDF) WJG-24-4880.pdf
Full Article (Word) WJG-24-4880.doc
The ARRIVE Guidelines 41169-The ARRIVE guidelines.pdf
Manuscript File 41169-Review.doc
Answering Reviewers 41169-Answering reviewers.pdf
Audio Core Tip 41169-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 41169-Conflict-of-interest statement.pdf
Copyright License Agreement 41169-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 41169-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 41169-Institutional review board statement.pdf
Supplementary Material 41169-Supplementary material.pdf
Peer-review Report 41169-Peer-review(s).pdf
Scientific Misconduct Check 41169-Scientific misconduct check.pdf
Scientific Editor Work List 41169-Scientific editor work list.pdf