BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
12/21/2018 1:32:15 AM | Browse: 1164 | Download: 1724
 |
Received |
|
2018-08-03 00:49 |
|
Peer-Review Started |
|
2018-08-04 07:15 |
|
First Decision by Editorial Office Director |
|
2018-08-31 17:25 |
|
Return for Revision |
|
2018-09-10 09:12 |
|
Revised |
|
2018-09-20 20:34 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2018-11-23 10:16 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2018-11-27 04:43 |
|
Articles in Press |
|
2018-11-27 04:43 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2018-12-17 03:14 |
|
Publish the Manuscript Online |
|
2018-12-21 01:32 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Role of senescence induction in cancer treatment
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Shenghui Qin, Bradley A Schulte and Gavin Yong Wang |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Gavin Yong Wang, MD, PhD, Assistant Professor, Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 171 Ashley Avenue, MSC908, Charleston, SC 29425, United States. wangy@musc.edu |
| Key Words |
Cellular senescence; Cancer treatment; Chemotherapy; Ionizing radiation; Cyclin-dependent kinases 4/6 inhibitor; Aurora kinase inhibitor; Immunotherapy; T helper-1 cells; Th1 cytokines |
| Core Tip |
Both in vitro and in vivo studies have revealed that senescence induction in human cancer cells is a prominent response to chemotherapy and irradiation. A senescent phenotype has been detected in clinical tumor samples of breast cancer patients following preoperative neoadjuvant chemotherapy. Immunotherapy-induced senescence of cancer cells contributes to tumor regression in vivo. The induction of cancer cell senescence appears to be a major mechanism of action of cyclin-dependent kinases 4/6 small molecule inhibitor-based targeted therapy. Collectively, these preclinical and clinical observations have demonstrated an important role for senescence induction in cancer treatment. |
| Publish Date |
2018-12-21 01:32 |
| Citation |
Qin S, Schulte BA, Wang GY. Role of senescence induction in cancer treatment. World J Clin Oncol 2018; 9(8): 180-187 |
| URL |
https://www.wjgnet.com/2218-4333/full/v9/i8/180.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v9.i8.180 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
