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Articles Published Processes
12/21/2018 1:32:15 AM | Browse: 970 | Download: 1246
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Received |
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2018-08-03 00:49 |
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Peer-Review Started |
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2018-08-04 07:15 |
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To Make the First Decision |
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2018-09-03 01:47 |
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Return for Revision |
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2018-09-10 09:12 |
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Revised |
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2018-09-20 20:34 |
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Second Decision |
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2018-11-23 10:16 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-11-27 04:43 |
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Articles in Press |
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2018-11-27 04:43 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-12-17 03:14 |
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Publish the Manuscript Online |
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2018-12-21 01:32 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Role of senescence induction in cancer treatment
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Shenghui Qin, Bradley A Schulte and Gavin Yong Wang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Gavin Yong Wang, MD, PhD, Assistant Professor, Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 171 Ashley Avenue, MSC908, Charleston, SC 29425, United States. wangy@musc.edu |
| Key Words |
Cellular senescence; Cancer treatment; Chemotherapy; Ionizing radiation; Cyclin-dependent kinases 4/6 inhibitor; Aurora kinase inhibitor; Immunotherapy; T helper-1 cells; Th1 cytokines |
| Core Tip |
Both in vitro and in vivo studies have revealed that senescence induction in human cancer cells is a prominent response to chemotherapy and irradiation. A senescent phenotype has been detected in clinical tumor samples of breast cancer patients following preoperative neoadjuvant chemotherapy. Immunotherapy-induced senescence of cancer cells contributes to tumor regression in vivo. The induction of cancer cell senescence appears to be a major mechanism of action of cyclin-dependent kinases 4/6 small molecule inhibitor-based targeted therapy. Collectively, these preclinical and clinical observations have demonstrated an important role for senescence induction in cancer treatment. |
| Publish Date |
2018-12-21 01:32 |
| Citation |
Qin S, Schulte BA, Wang GY. Role of senescence induction in cancer treatment. World J Clin Oncol 2018; 9(8): 180-187 |
| URL |
https://www.wjgnet.com/2218-4333/full/v9/i8/180.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v9.i8.180 |
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