Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	4119
Country	United States

Received	2013-06-15 10:08
Peer-Review Started	2013-06-16 10:01
To Make the First Decision	2013-07-19 08:31
Return for Revision	2013-07-19 16:16
Revised	2013-07-31 22:43
Second Decision	2013-08-06 16:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-08-06 23:12
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-10-09 14:29
Publish the Manuscript Online	2013-11-04 12:31

ISSN	2150-5349 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Eosinophils and mast cells as therapeutic targets in pediatric functional dyspepsia
Manuscript Source	Invited Manuscript
All Author List	Craig A Friesen, Jennifer V Schurman, Jennifer M Colombo and Susan M Abdel-Rahman
Funding Agency and Grant Number
Corresponding Author	Craig A Friesen, MD, Division of Gastroenterology, Hepatology and Nutrition, the Children’s Mercy Hospital and Clinics, 2401 Gillham Road, Kansas City, Missouri, MO 64108, United States. cfriesen@cmh.edu
Key Words	Eosinophils; Mast cells; Functional dyspepsia; Abdominal pain; Stress
Core Tip	Current evidence implicates gastric mast cells and duodenal eosinophils in the pathophysiology of functional dyspepsia and as mediators between psychologic and physiologic factors. Increased antral mast cell density is associated with anxiety, electromechanical dysfunction, and the postprandial distress syndrome (PDS) subtype of functional dyspepsia. Likewise, increased duodenal eosinophil density is associated with anxiety and the PDS subtype, however, effects on electromechanical function are more indirect. More importantly, mast cells and eosinophils appear to be therapeutic targets offering newer options for treating functional dyspepsia.
Publish Date	2013-11-04 12:31
Citation	Friesen CA, Schurman JV, Colombo JM, Abdel-Rahman SM. Eosinophils and mast cells as therapeutic targets in pediatric functional dyspepsia. World J Gastrointest Phar-macol Ther 2013; 4(4): 86-96
URL	http://www.wjgnet.com/2150-5349/full/v4/i4/86.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v4.i4.86

Full Article (PDF)	WJGPT-4-86.pdf
Manuscript File	4119-Review.doc
Answering Reviewers	4119-Answering reviewers.pdf
Copyright License Agreement	4119-Copyright assignment.pdf
Peer-review Report	4119-Peer reviews.pdf
Scientific Editor Work List	4119-Scientific editor work list.doc