Publication Name	World Journal of Gastroenterology
Manuscript ID	41221
Country	China

Received	2018-08-08 07:10
Peer-Review Started	2018-08-08 07:56
To Make the First Decision	2018-10-08 02:05
Return for Revision	2018-10-08 09:25
Revised	2018-10-19 05:20
Second Decision	2018-10-26 07:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-10-27 01:00
Articles in Press	2018-10-27 01:00
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-10-31 02:04
Typeset the Manuscript	2018-11-09 05:53
Publish the Manuscript Online	2018-11-13 08:04

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Yiguanjian decoction enhances fetal liver stem/progenitor cell-mediated repair of liver cirrhosis through regulation of macrophage activation state
Manuscript Source	Unsolicited Manuscript
All Author List	Ying Xu, Wei-Wei Fan, Wen Xu, Shi-Li Jiang, Gao-Feng Chen, Cheng Liu, Jia-Mei Chen, Hua Zhang, Ping Liu and Yong-Ping Mu
ORCID	Author(s) ORCID Number Ying Xu http://orcid.org/0000-0002-4645-3094 Wei-Wei Fan http://orcid.org/0000-0002-0016-0595 Wen Xu http://orcid.org/0000-0003-2132-9537 Shi-Li Jiang http://orcid.org/0000-0002-2171-0488 Gao-Feng Chen http://orcid.org/0000-0002-1266-7086 Cheng Liu http://orcid.org/0000-0002-8741-6169 Jia-Mei Chen http://orcid.org/0000-0001-9808-9610 Hua Zhang http://orcid.org/0000-0003-0680-2314 Ping Liu http://orcid.org/0000-0002-6152-4508 Yong-Ping Mu http://orcid.org/0000-0002-4533-5563
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81173223 National Natural Science Foundation of China 81573948 National Natural Science Foundation of China 81874390
Corresponding Author	Yong-Ping Mu, PhD, Attending Doctor, Department of gastroenterology and Hepatology, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Road, Pudong district, Shanghai 201203, China. ypmu8888@126.com
Key Words	Cirrhosis; Hepatic progenitor cells; Wnt signaling pathway; Macrophage; 2-acetylaminofluorene; Carbon tetrachloride; Yiguanjian decoction
Core Tip	Stem cells play an important role in the treat­ment of end-stage liver cirrhosis, but details concerning their differentiation are still controversial. Our previous studies have indicated that Yiguanjian decoction (YGJ) has an anti-hepatic fibrosis effect. However, it remains unclear whether YGJ regulates stem cell differentiation. In this work, we found that YGJ may enhance fetal liver stem/progenitor cell-mediated repair of liver cirrhosis through regulation of macrophage activation state in cirrhosis, suggesting that YGJ in combination with stem cell transplantation may be a suitable treatment for end-stage liver cirrhosis.
Publish Date	2018-11-13 08:04
Citation	Xu Y, Fan WW, Xu W, Jiang SL, Chen GF, Liu C, Chen JM, Zhang H, Liu P, Mu YP. Yiguanjian decoction enhances fetal liver stem/progenitor cell-mediated repair of liver cirrhosis through regulation of macrophage activation state. World J Gastroenterol 2018; 24(42): 4759-4772
URL	http://www.wjgnet.com/1007-9327/full/v24/i42/4759.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i42.4759

Full Article (PDF)	WJG-24-4759.pdf
Full Article (Word)	WJG-24-4759.doc
The ARRIVE Guidelines	41221-The ARRIVE guidelines.pdf
Manuscript File	41221-Review.docx
Answering Reviewers	41221-Answering reviewers.pdf
Audio Core Tip	41221-Audio core tip.mp3
Biostatistics Review Certificate	41221-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	41221-Conflict-of-interest statement.pdf
Copyright License Agreement	41221-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	41221-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	41221-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	41221-Language certificate.pdf
Supplementary Material	41221-Supplementary material.pdf
Peer-review Report	41221-Peer-review(s).pdf
Scientific Misconduct Check	41221-Scientific misconduct check.pdf
Scientific Editor Work List	41221-Scientific editor work list.pdf