| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Overexpression of insulin-like growth factor-Ⅰ receptor as a pertinent biomarker for hepatocytes malignant transformation
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Xiao-Di Yan, Min Yao, Li Wang, Hai-Jian Zhang, Mei-Juan Yan, Xing Gu, Yun Shi, Jie Chen, Zhi-Zhen Dong and Deng-Fu Yao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Society Development of Nantong |
HS2012039 |
| Jiangsu Health Projects, |
BL2012053 |
| Jiangsu Health Projects |
K201102 |
| Priority Academic Program Development of Jiangsu, and the International S and T Cooperation Program of China |
2013DFA32150 |
|
| Corresponding Author |
Deng-Fu Yao, MD, PhD, Professor, Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, 20 West Temple Road, Nantong 226001, Jiangsu Province, China. yaodf@ahnmc.com |
| Key Words |
Hepatoma; Insulin-like growth factor-Ⅰ receptor; Immunohistochemistry; Gene amplification; Sequencing; Rat hepatoma model |
| Core Tip |
The abnormality of insulin-like growth factor-Ⅰ receptor (IGF-ⅠR) expression was progressively increased in hepatocarcinogenesis at mRNA or protein level, and there was a positive correlation between circulating blood and liver IGF-ⅠR, suggesting that the over-expression of liver IGF-ⅠR release into blood, and serum IGF-ⅠR should be an early useful marker for monitoring malignant transformation of rat hepatocytes. |
| Publish Date |
2013-09-26 18:39 |
| Citation |
Yan XD, Yao M, Wang L, Zhang HJ, Yan MJ, Gu X, Shi Y, Chen J, Dong ZZ, Yao DF. Overexpression of insulin-like growth factor-Ⅰ?receptor as a pertinent biomarker for hepatocytes malignant transformation. World J Gastroenterol 2013; 19(36): 6084-6092 |
| URL |
http://www.wjgnet.com/1007-9327/full/v19/i36/6084.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v19.i36.6084 |
