Publication Name	World Journal of Gastroenterology
Manuscript ID	4125
Country	China

Received	2013-06-17 08:11
Peer-Review Started	2013-06-18 08:56
First Decision by Editorial Office Director
Return for Revision	2013-07-14 20:19
Revised	2013-08-15 17:19
Publication Fee Transferred
Second Decision by Editor	2013-08-20 10:29
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-08-20 12:50
Articles in Press
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-09-11 09:29
Publish the Manuscript Online	2013-09-26 18:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Overexpression of insulin-like growth factor-Ⅰ receptor as a pertinent biomarker for hepatocytes malignant transformation
Manuscript Source	Invited Manuscript
All Author List	Xiao-Di Yan, Min Yao, Li Wang, Hai-Jian Zhang, Mei-Juan Yan, Xing Gu, Yun Shi, Jie Chen, Zhi-Zhen Dong and Deng-Fu Yao
Funding Agency and Grant Number	Funding Agency Grant Number Society Development of Nantong HS2012039 Jiangsu Health Projects, BL2012053 Jiangsu Health Projects K201102 Priority Academic Program Development of Jiangsu, and the International S and T Cooperation Program of China 2013DFA32150
Corresponding Author	Deng-Fu Yao, MD, PhD, Professor, Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, 20 West Temple Road, Nantong 226001, Jiangsu Province, China. yaodf@ahnmc.com
Key Words	Hepatoma; Insulin-like growth factor-Ⅰ receptor; Immunohistochemistry; Gene amplification; Sequencing; Rat hepatoma model
Core Tip	The abnormality of insulin-like growth factor-Ⅰ receptor (IGF-ⅠR) expression was progressively increased in hepatocarcinogenesis at mRNA or protein level, and there was a positive correlation between circulating blood and liver IGF-ⅠR, suggesting that the over-expression of liver IGF-ⅠR release into blood, and serum IGF-ⅠR should be an early useful marker for monitoring malignant transformation of rat hepatocytes.
Publish Date	2013-09-26 18:39
Citation	Yan XD, Yao M, Wang L, Zhang HJ, Yan MJ, Gu X, Shi Y, Chen J, Dong ZZ, Yao DF. Overexpression of insulin-like growth factor-Ⅰ?receptor as a pertinent biomarker for hepatocytes malignant transformation. World J Gastroenterol 2013; 19(36): 6084-6092
URL	http://www.wjgnet.com/1007-9327/full/v19/i36/6084.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i36.6084

Full Article (PDF)	WJG-19-6084.pdf
Manuscript File	4125-Review.doc
Answering Reviewers	4125-Answering reviewers.pdf
Copyright License Agreement	4125-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4125-Language certificate.pdf
Peer-review Report	4125-Peer reviews.pdf
Scientific Editor Work List	4125-Scientific editor work list.doc