Publication Name	World Journal of Hepatology
Manuscript ID	41263
Country	Argentina

Received	2018-08-06 03:50
Peer-Review Started	2018-08-07 00:40
To Make the First Decision	2018-08-27 01:11
Return for Revision	2018-09-04 11:02
Revised	2018-09-05 00:41
Second Decision	2018-09-19 07:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-10-11 23:38
Articles in Press	2018-10-11 23:38
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-10-20 19:46
Typeset the Manuscript	2018-12-24 13:39
Publish the Manuscript Online	2018-12-27 09:28

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Unresolved issues in the prophylaxis of bacterial infections in patients with cirrhosis
Manuscript Source	Invited Manuscript
All Author List	Melisa Dirchwolf, Sebastian Marciano, Jose Martinez and Andres Eduardo Ruf
ORCID	Author(s) ORCID Number Melisa Dirchwolf http://orcid.org/0000-0002-9083-3561 Sebastian Marciano http://orcid.org/0000-0002-7983-1450 Jose Martinez http://orcid.org/0000-0002-7633-3229 Andres Eduardo Ruf http://orcid.org/0000-0002-8225-2775
Funding Agency and Grant Number
Corresponding Author	Melisa Dirchwolf, MD, Attending Doctor, Unidad de Higado, Hospital Privado de Rosario, Presidente Roca 2440, Rosario 2000, Santa Fe, Argentina. unidaddehigado.hpr@grupogamma.com.ar
Key Words	Cirrhosis; Antibiotic Prophylaxis; Multi-drug resistant bacteria; Spontaneous bacterial peritonitis; Bacterial infections
Core Tip	Antibiotic prophylaxis in cirrhosis patients has proven to be effective in preventing new episodes of bacterial infections and reducing mortality. However, the broad and fixed indication of long-term antibiotic therapy in these patients has led to an increase in the emergence of multi-drug resistant bacteria. The development of new strategies for bacterial infection prevention is currently under debate, thus reflecting the need for randomized controlled trials and local epidemiological studies to improve prophylactic antibiotic choice in patients with cirrhosis.
Publish Date	2018-12-27 09:28
Citation	Dirchwolf M, Marciano S, Martínez J, Ruf AE. Unresolved issues in the prophylaxis of bacterial infections in patients with cirrhosis. World J Hepatol 2018; 10(12): 892-897
URL	https://www.wjgnet.com/1948-5182/full/v10/i12/892.htm
DOI	https://dx.doi.org/10.4254/wjh.v10.i12.892

Full Article (PDF)	WJH-10-892.pdf
Full Article (Word)	WJH-10-892.doc
Manuscript File	41263-Review.docx
Answering Reviewers	41263-Answering reviewers.pdf
Audio Core Tip	41263-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	41263-Conflict-of-interest statement.pdf
Copyright License Agreement	41263-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	41263-Language certificate.pdf
Peer-review Report	41263-Peer-review(s).pdf
Scientific Misconduct Check	41263-Scientific misconduct check.pdf
Scientific Editor Work List	41263-Scientific editor work list.pdf