Publication Name	World Journal of Gastroenterology
Manuscript ID	41403
Country	United States

Received	2018-08-06 01:18
Peer-Review Started	2018-08-06 01:38
To Make the First Decision	2018-10-11 09:19
Return for Revision	2018-10-12 02:27
Revised	2018-10-13 09:07
Second Decision	2018-10-19 09:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-10-21 06:38
Articles in Press	2018-10-21 06:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-11-09 02:54
Publish the Manuscript Online	2018-11-21 04:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Cryotherapy in the management of premalignant and malignant conditions of the esophagus
Manuscript Source	Invited Manuscript
All Author List	Pooja Lal and Prashanthi N Thota
ORCID	Author(s) ORCID Number Pooja Lal http://orcid.org/0000-0001-9425-4025 Prashanthi N Thota http://orcid.org/0000-0001-7179-4774
Funding Agency and Grant Number
Corresponding Author	Prashanthi N Thota, MD, Staff Physician, Department of Gastroenterology and Hepatology, Digestive Disease Surgery Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, United States. thotap@ccf.org
Key Words	Esophageal cancer; Barrett’s esophagus; Palliative therapy; Cryotherapy
Core Tip	Cryotherapy is freezing of tissue to destroy abnormal lesions and has evolving role in mangement of premalignant and malignant conditions of the esophagus. The currently available cryoablation systems in esophagus are cryospray using liquid nitrogen and cryoballoon focal ablation system using liquid nitrous oxide. The eradication rates of metaplasia and dysplasia in Barrett’s esophagus (BE) with cryotherapy are comparable to those with radiofrequency ablation (RFA). In addition, cryotherapy can be used when RFA is ineffective or not possible in patients with BE and for palliative purposes in advanced esophageal cancer.
Publish Date	2018-11-21 04:08
Citation	Lal P, Thota PN. Cryotherapy in the management of premalignant and malignant conditions of the esophagus. World J Gastroenterol 2018; In press
URL	http://www.wjgnet.com/1007-9327/full/v24/i43/4862.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i43.4862

Full Article (PDF)	WJG-24-4862.pdf
Full Article (Word)	WJG-24-4862.doc
Manuscript File	41403-Review.docx
Answering Reviewers	41403-Answering reviewers.pdf
Audio Core Tip	41403-Audio core tip.wma
Conflict-of-Interest Disclosure Form	41403-Conflict-of-interest statement.pdf
Copyright License Agreement	41403-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	41403-Approved-Grant-Application-Form(s)-or-Funding-Agency-Copy-of-any-Approval-Document(s)-revision.docx
Non-Native Speakers of English Editing Certificate	41403-Non-Native-Speakers-of-English-Editing-Certificate-revision.docx
Peer-review Report	41403-Peer-review(s).pdf
Scientific Misconduct Check	41403-Scientific misconduct check.pdf
Scientific Editor Work List	41403-Scientific editor work list.pdf