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11/21/2018 4:08:59 AM | Browse: 206 | Download: 121
Publication Name World Journal of Gastroenterology
Manuscript ID 41476
Country of Manuscript Source Italy
Received
2018-08-09 00:22
Peer-Review Started
2018-08-09 07:09
To Make the First Decision
2018-10-08 03:47
Return for Revision
2018-10-08 08:07
Revised
2018-10-22 14:22
Second Decision
2018-11-02 09:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-11-02 17:02
Articles in Press
2018-11-02 17:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-11-10 05:25
Publish the Manuscript Online
2018-11-21 04:08
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Editorial
Article Title Promoting genetics in non-alcoholic fatty liver disease: Combined risk score through polymorphisms and clinical variables
Manuscript Source Invited Manuscript
All Author List Umberto Vespasiani-Gentilucci, Paolo Gallo, Chiara Dell'Unto, Mara Volpentesta, Raffaele Antonelli-Incalzi and Antonio Picardi
ORCID
Author(s) ORCID Number
Umberto Vespasiani-Gentilucci http://orcid.org/0000-0002-1138-1967
Paolo Gallo http://orcid.org/0000-0001-8292-1134
Chiara Dell'Unto http://orcid.org/0000-0003-3499-6750
Mara Volpentesta http://orcid.org/0000-0002-7377-9188
Raffaele Antonelli-Incalzi http://orcid.org/0000-0003-2100-2075
Antonio Picardi http://orcid.org/0000-0002-0230-218X
Funding Agency and Grant Number
Corresponding author Antonio Picardi, MD, PhD, Professor, Unit of Internal Medicine and Hepatology, Department of Medicine, University Campus Bio-Medico, Via Alvaro del Portillo 200, Rome 00128, Italy. a.picardi@unicampus.it
Keywords Non-alcoholic fatty liver disease; Single nucleotide polymorphism; Patatin-like phospholipase domain-containing protein 3; Transmembrane 6 super­family member 2; Membrane bound O-acyltransferase domain containing 7; Glucokinase regulatory gene; Risk score; Non-alcoholic steatohepatitis; Non-alcoholic steatohepatitis cirrhosis; Hepatocellular carcinoma
Core Tip Risk stratification is emerging as fundamental in the non-alcoholic fatty liver disease (NAFLD) epidemic. Due to the strong heritability of hepatic fat content and of liver fibrosis progression, genetics is perfectly suitable to fulfill this task. However, notwithstanding the fact that different gene variants have been robustly associated with NAFLD and with its evolution, translation to the clinical ground has been poor or absent. The evidence produced suggests that combined risk scores, created by integrating different genetic and clinical information and tested with respect to relevant outcomes in longitudinal studies, may represent the way for genetics to gain strength in NAFLD diagnostics.
Publish Date 2018-11-21 04:08
Citation Vespasiani-Gentilucci U, Gallo P, Dell’Unto C, Volpentesta M, Antonelli-Incalzi R, Picardi A. Promoting genetics in non-alcoholic fatty liver disease: Combined risk score through polymorphisms and clinical variables. World J Gastroenterol 2018; 24(43): 4835-4845
Url http://www.wjgnet.com/1007-9327/full/v24/i43/4835.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i43.4835
Full Article (PDF) WJG-24-4835.pdf
Full Article (Word) WJG-24-4835.doc
Manuscript File 41476-Review.docx
Answering Reviewers 41476-Answering reviewers.pdf
Audio Core Tip 41476-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 41476-Conflict-of-interest statement.pdf
Copyright License Agreement 41476-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 41476-Language certificate.pdf
Peer-review Report 41476-Peer-review(s).pdf
Scientific Misconduct Check 41476-Scientific misconduct check.pdf
Scientific Editor Work List 41476-Scientific editor work list.pdf