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Articles Published Processes
11/27/2018 5:55:53 AM | Browse: 882 | Download: 1461
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Received |
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2018-08-20 00:49 |
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Peer-Review Started |
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2018-08-20 02:53 |
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To Make the First Decision |
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2018-10-08 03:35 |
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Return for Revision |
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2018-10-11 00:48 |
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Revised |
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2018-10-14 15:01 |
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Second Decision |
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2018-11-07 09:19 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-11-08 02:39 |
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Articles in Press |
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2018-11-08 02:39 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-11-14 07:49 |
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Typeset the Manuscript |
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2018-11-27 01:59 |
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Publish the Manuscript Online |
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2018-11-27 05:55 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Involvement of methylation-associated silencing of formin 2 in colorectal carcinogenesis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Dao-Jiang Li, Zhi-Cai Feng, Xiao-Rong Li and Gui Hu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Nature Science Foundation of China |
No. 81773130 |
| The New Xiangya Talent Projects of the Third Xiangya Hospital of Central South University |
No.JY201508 |
| The Key Projects of Postgraduate Independent Exploration and Innovation of The Central South University |
2018zzts050 |
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| Corresponding Author |
Gui Hu, PhD, Surgeon, Department of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South University, Tongzi Po Road, No. 172, Changsha 410013, Hunan Province, China. xy3zzz@csu.edu.cn |
| Key Words |
Formin 2; Colorectal cancer; Methylation; Methylation-associated silencing; Early-stage cancer |
| Core Tip |
Colorectal cancer (CRC) is the leading cause of cancer death in the world. We identified a statistically significant downregulation of formin 2 (FMN2) expression in large-scale human CRC expression datasets and our clinical samples. Then, we first showed that a high frequency of hypermethylation occurred in the FMN2 gene promoter, which is responsible for the downregulation of FMN2 expression. Additionally, the highest methylation of FMN2 occurred in tissues from cases of early-stage CRC and patients > 60 years old. FMN2 hypermethylation may be an important early event in CRC and can serve as an ideal diagnostic biomarker in elderly patients with early-stage CRC. |
| Publish Date |
2018-11-27 05:55 |
| Citation |
Li DJ, Feng ZC, Li XR, Hu G. Involvement of methylation-associated silencing of formin 2 in colorectal carcinogenesis. World J Gastroenterol 2018; 24(44): 5013-5024 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i44/5013.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i44.5013 |
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