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1/30/2019 5:59:07 AM | Browse: 142 | Download: 68
Publication Name World Journal of Gastroenterology
Manuscript ID 41640
Country of Manuscript Source Lebanon
Received
2018-09-10 07:30
Peer-Review Started
2018-09-10 07:41
To Make the First Decision
2018-10-11 09:15
Return for Revision
2018-10-12 02:20
Revised
2018-12-02 15:04
Second Decision
2018-12-06 10:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-12-07 03:32
Articles in Press
2018-12-07 03:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-12-18 03:55
Typeset the Manuscript
2019-01-29 06:56
Publish the Manuscript Online
2019-01-30 05:59
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Effect of adipose-derived mesenchymal stem cells on hepatocellular carcinoma: In vitro inhibition of carcinogenesis
Manuscript Source Unsolicited Manuscript
All Author List Rim Serhal, Nagib Saliba, George Hilal, Mayssam Moussa, Ghada S Hassan, Oula El Atat and Nada Alaaeddine
ORCID
Author(s) ORCID Number
Rim Serhal http://orcid.org/0000-0003-1349-1454
Nagib Saliba http://orcid.org/0000-0003-1778-9848
George Hilal http://orcid.org/0000-0001-7629-4090
Mayssam Moussa http://orcid.org/0000-0003-3214-9304
Ghada S Hassan http://orcid.org/0000-0002-1391-5248
Oula El Atat http://orcid.org/0000-0003-1341-0204
Nada Alaaeddine http://orcid.org/0000-0002-1748-4473
Funding Agency and Grant Number
Corresponding author Nada Alaaeddine, PhD, Professor, Laboratoire d Immunologie Cellulaire, Moléculaire Centre Hospitalier, Université de Montréal, 900 rue saint dénis, Montreal 10482, Canada. Naladdin@gu.edu.lb
Keywords Hepatocellular carcinoma; Adipose-derived mesenchymal stem cells; Adipose-derived mesenchymal stem cell conditioned media; Proliferation; Apoptosis; Migration; Invasion
Core Tip In this study, we report the in vitro effect of adipose derived mesenchymal stem cells (ADMSCs) on HepG2 and PLC-PRF-5 liver cell lines. It is the first study to demonstrate that ADMSCs and their respective conditioned media inhibited the expression of hepatocellular carcinoma markers alpha-fetoprotein and Des-gamma-carboxy-prothrombin and decreased cancer cell invasiveness by increasing the mRNA expression of tissue inhibitor metalloproteinases TIMP-1, TIMP-2 and TIMP-3. In addition, ADMSCs significantly reduced the proliferation rate, the invasiveness and the migration of the cancer cells while inducing their apoptosis.
Publish Date 2019-01-30 05:59
Citation Serhal R, Saliba N, Hilal G, Moussa M, Hassan G, El Atat O, Alaaeddine N. Effect of adipose derived mesenchymal stem cells on hepatocellular carcinoma: In vitro inhibition of carcinogenesis. World J Gastroenterol 2019; 25(5): 567-583
Url https://www.wjgnet.com/1007-9327/full/v25/i5/567.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i5.567
Full Article (PDF) WJG-25-567.pdf
Full Article (Word) WJG-25-567.docx
Manuscript File 41640-Review.docx
Answering Reviewers 41640-Answering reviewers.pdf
Audio Core Tip 41640-Audio core tip.m4a
Biostatistics Review Certificate 41640-Biostatistics-Review-Certificate-revision_0101.pdf
Conflict-of-Interest Disclosure Form 41640-Conflict-of-interest statement.pdf
Copyright License Agreement 41640-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 41640-Institutional-Animal-Care-and-Use-Committee-Approval-Form-or-Document-revision.pdf
Institutional Review Board Approval Form or Document 41640-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 41640-Non-Native Speakers of English Editing Certificate.pdf
Supplementary Material 41640-Supplementary material.pdf
Peer-review Report 41640-Peer-review(s).pdf
Scientific Misconduct Check 41640-Scientific misconduct check.pdf
Scientific Editor Work List 41640-Scientific editor work list.pdf