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Articles Published Processes
1/30/2019 5:59:07 AM | Browse: 1060 | Download: 1896
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Received |
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2018-09-10 07:30 |
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Peer-Review Started |
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2018-09-10 07:41 |
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To Make the First Decision |
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2018-10-11 09:15 |
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Return for Revision |
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2018-10-12 02:20 |
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Revised |
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2018-12-02 15:04 |
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Second Decision |
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2018-12-06 10:05 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-12-07 03:32 |
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Articles in Press |
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2018-12-07 03:32 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-12-18 03:55 |
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Typeset the Manuscript |
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2019-01-29 06:56 |
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Publish the Manuscript Online |
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2019-01-30 05:59 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Effect of adipose-derived mesenchymal stem cells on hepatocellular carcinoma: In vitro inhibition of carcinogenesis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Rim Serhal, Nagib Saliba, George Hilal, Mayssam Moussa, Ghada S Hassan, Oula El Atat and Nada Alaaeddine |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Nada Alaaeddine, PhD, Professor, Laboratoire d Immunologie Cellulaire, Moléculaire Centre Hospitalier, Université de Montréal, 900 rue saint dénis, Montreal 10482, Canada. naladdin@gu.edu.lb |
| Key Words |
Hepatocellular carcinoma; Adipose-derived mesenchymal stem cells; Adipose-derived mesenchymal stem cell conditioned media; Proliferation; Apoptosis; Migration; Invasion |
| Core Tip |
In this study, we report the in vitro effect of adipose derived mesenchymal stem cells (ADMSCs) on HepG2 and PLC-PRF-5 liver cell lines. It is the first study to demonstrate that ADMSCs and their respective conditioned media inhibited the expression of hepatocellular carcinoma markers alpha-fetoprotein and Des-gamma-carboxy-prothrombin and decreased cancer cell invasiveness by increasing the mRNA expression of tissue inhibitor metalloproteinases TIMP-1, TIMP-2 and TIMP-3. In addition, ADMSCs significantly reduced the proliferation rate, the invasiveness and the migration of the cancer cells while inducing their apoptosis. |
| Publish Date |
2019-01-30 05:59 |
| Citation |
Serhal R, Saliba N, Hilal G, Moussa M, Hassan G, El Atat O, Alaaeddine N. Effect of adipose derived mesenchymal stem cells on hepatocellular carcinoma: In vitro inhibition of carcinogenesis. World J Gastroenterol 2019; 25(5): 567-583 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i5/567.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i5.567 |
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