Publication Name	World Journal of Gastroenterology
Manuscript ID	41677
Country	China

Received	2018-08-24 02:03
Peer-Review Started	2018-08-24 02:30
To Make the First Decision	2018-10-08 03:05
Return for Revision	2018-10-08 08:48
Revised	2018-11-07 02:52
Second Decision	2018-11-07 09:03
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-11-08 02:36
Articles in Press	2018-11-08 02:36
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-11-12 23:41
Typeset the Manuscript	2018-11-27 01:58
Publish the Manuscript Online	2018-11-27 05:55

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Different distributions of interstitial cells of Cajal and platelet-derived growth factor receptor-α positive cells in colonic smooth muscle cell/interstitial cell of Cajal/platelet-derived growth factor receptor-α positive cell syncytium in mice
Manuscript Source	Unsolicited Manuscript
All Author List	Chen Lu, Xu Huang, Hong-Li Lu, Shao-Hua Liu, Jing-Yu Zang, Yu-Jia Li, Jie Chen and Wen-Xie Xu
ORCID	Author(s) ORCID Number Chen Lu http://orcid.org/0000-0001-8020-0501 Xu Huang http://orcid.org/0000-0002-8640-5177 Hong-Li Lu http://orcid.org/0000-0001-5374-8336 Shao-Hua Liu http://orcid.org/0000-0001-8359-3758 Jing-Yu Zang http://orcid.org/0000-0002-6646-9341 Yu-Jia Li http://orcid.org/0000-0001-8614-2234 Jie Chen http://orcid.org/0000-0003-2308-0130 Wen-Xie Xu http://orcid.org/0000-0003-3040-4340
Funding Agency and Grant Number	Funding Agency Grant Number the National Natural Science Foundation of China 31671192 and 31571180 Foundation of Xin Hua Hospital JZPI201708
Corresponding Author	Wen-Xie Xu, PhD, Professor, Department of Physiology, Shanghai Jiao Tong University School of Medicine, 328 Wenxuan Medical Building, 800 Dongchuan Road, Shanghai 200240, China. wenxiexu@sjtu.edu.cn
Key Words	Interstitial cells of Cajal; Platelet-derived growth factor receptor-α positive cells; Smooth muscle cell/interstitial cell of Cajal/platelet-derived growth factor receptor-α positive cell syncytium; Nitric oxide; Purine
Core Tip	The different distributions of interstitial cells of Cajal (ICCs) and platelet-derived growth factor receptor-α positive (PDGFRα+) cells in the different parts of the colon result in a pressure gradient in the colon that propels the feces to the anus. Nitric oxide (NO) is mainly involved in the regulation of contraction through ICCs, and purine mainly participates in relaxation through PDGFRα+ cells. The regulation of the inhibitory transmitter NO and purine through the two kinds of interstitial cells (ICCs and PDGFRα+ cells) is very important for rhythmic colonic migrating motor complexes, which are the main driving force underlying colon transit.
Publish Date	2018-11-27 05:55
Citation	Lu C, Huang X, Lu HL, Liu SH, Zang JY, Li YJ, Chen J, Xu WX. Different distributions of interstitial cells of Cajal and platelet-derived growth factor receptor-α positive cells in colonic smooth muscle cell/interstitial cell of Cajal/platelet-derived growth factor receptor-α positive cell syncytium in mice. World J Gastroenterol 2018; 24(44): 4989-5004
URL	http://www.wjgnet.com/1007-9327/full/v24/i44/4989.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i44.4989

Full Article (PDF)	WJG-24-4989.pdf
Full Article (Word)	WJG-24-4989.doc
The ARRIVE Guidelines	41677-The ARRIVE guidelines.pdf
Manuscript File	41677-Review.docx
Answering Reviewers	41677-Answering reviewers.pdf
Audio Core Tip	41677-Audio core tip.mp3
Biostatistics Review Certificate	41677-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	41677-Conflict-of-interest statement.pdf
Copyright License Agreement	41677-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	41677-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	41677-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	41677-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	41677-Language certificate.pdf
Supplementary Material	41677-Supplementary material.pdf
Peer-review Report	41677-Peer-review(s).pdf
Scientific Misconduct Check	41677-Scientific misconduct check.pdf
Scientific Editor Work List	41677-Scientific editor work list.pdf