Category |
Gastroenterology & Hepatology |
Manuscript Type |
Autobiography |
Article Title |
Risk factors for hepatocellular carcinoma in patients with drug-resistant chronic hepatitis B
|
Manuscript Source |
Invited Manuscript |
All Author List |
Chung Hwan Jun, Hyoung Ju Hong, Min Woo Chung, Seon Young Park, Sung Bum Cho, Chang Hwan Park, Young Eun Joo, Hyun Soo Kim, Sung Kyu Choi and Jong Sun Rew |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Chonnam National University Hospital 42, South Korea |
|
|
Corresponding Author |
Sung Kyu Choi, MD, Division of Gastroenterology, Department of Internal Medicine, Chonnam National University Medical School, 42, Jaebong-ro, Dong-Ku, Gwangju 501-757, South Korea. estevanj@naver.com |
Key Words |
Carcinoma; Hepatocellular; Hepatitis B; Drug resistance; Risk factors; Characteristics |
Core Tip |
There are few studies on hepatocarcinogenesis in patients with drug-resistant chronic hepatitis B (CHB) or on the characteristics of tumors arising from drug-resistant CHB. In the present study, the cumulative incidence rate of hepatocellular carcinoma (HCC) in patients with drug-resistant CHB was 4.6%, 6.9%, 8.87%, and 11.8% at the end of 1, 2, 3, and 5 years, respectively. Additionally, cirrhosis, age > 50 years, HBeAg (+), YIDD mutations, and a virologic non-responder status were independent risk factors for the development of HCC in CHB patients with drug resistance. Furthermore, there was a trend of poorer survival in patients with HCC arising from resistant CHB than in patients with HCC arising from naive CHB. |
Publish Date |
2013-11-13 08:37 |
Citation |
Jun CH, Hong HJ, Chung MW, Park SY, Cho SB, Park CH, Joo YE, Kim HS, Choi SK, Rew JS. Risk factors for hepatocellular carcinoma in patients with drug-resistant chronic hepatitis B. World J Gastroenterol 2013; 19(40): 6834-6841 |
URL |
http://www.wjgnet.com/1007-9327/full/v19/i40/6834.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v19.i40.6834 |