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9/12/2014 8:41:00 PM | Browse: 961 | Download: 963
Publication Name World Journal of Gastroenterology
Manuscript ID 4173
Country/Territory South Korea
Received
2013-06-20 09:26
Peer-Review Started
2013-06-20 09:58
To Make the First Decision
2013-07-19 08:56
Return for Revision
2013-07-20 22:59
Revised
2013-08-10 18:38
Second Decision
2013-09-03 14:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-09-04 07:44
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-10-19 20:22
Publish the Manuscript Online
2013-11-13 08:37
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Autobiography
Article Title Risk factors for hepatocellular carcinoma in patients with drug-resistant chronic hepatitis B
Manuscript Source Invited Manuscript
All Author List Chung Hwan Jun, Hyoung Ju Hong, Min Woo Chung, Seon Young Park, Sung Bum Cho, Chang Hwan Park, Young Eun Joo, Hyun Soo Kim, Sung Kyu Choi and Jong Sun Rew
Funding Agency and Grant Number
Funding Agency Grant Number
Chonnam National University Hospital 42, South Korea
Corresponding Author Sung Kyu Choi, MD, Division of Gastroenterology, Department of Internal Medicine, Chonnam National University Medical School, 42, Jaebong-ro, Dong-Ku, Gwangju 501-757, South Korea. estevanj@naver.com
Key Words Carcinoma; Hepatocellular; Hepatitis B; Drug resistance; Risk factors; Characteristics
Core Tip There are few studies on hepatocarcinogenesis in patients with drug-resistant chronic hepatitis B (CHB) or on the characteristics of tumors arising from drug-resistant CHB. In the present study, the cumulative incidence rate of hepatocellular carcinoma (HCC) in patients with drug-resistant CHB was 4.6%, 6.9%, 8.87%, and 11.8% at the end of 1, 2, 3, and 5 years, respectively. Additionally, cirrhosis, age > 50 years, HBeAg (+), YIDD mutations, and a virologic non-responder status were independent risk factors for the development of HCC in CHB patients with drug resistance. Furthermore, there was a trend of poorer survival in patients with HCC arising from resistant CHB than in patients with HCC arising from naive CHB.
Publish Date 2013-11-13 08:37
Citation Jun CH, Hong HJ, Chung MW, Park SY, Cho SB, Park CH, Joo YE, Kim HS, Choi SK, Rew JS. Risk factors for hepatocellular carcinoma in patients with drug-resistant chronic hepatitis B. World J Gastroenterol 2013; 19(40): 6834-6841
URL http://www.wjgnet.com/1007-9327/full/v19/i40/6834.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i40.6834
Full Article (PDF) WJG-19-6834.pdf
Manuscript File 4173-Review.doc
Answering Reviewers 4173-Answering reviewers.pdf
Copyright License Agreement 4173-Copyright assignment.doc
Non-Native Speakers of English Editing Certificate 4173-Language certificate.pdf
Peer-review Report 4173-Peer review(s).pdf
Scientific Editor Work List 4173-Scientific editor work list.doc