Publication Name	World Journal of Gastroenterology
Manuscript ID	4179
Country	Germany

Received	2013-06-19 09:40
Peer-Review Started	2013-06-20 09:41
First Decision by Editorial Office Director
Return for Revision	2013-10-19 15:44
Revised
Publication Fee Transferred
Second Decision by Editor	2014-01-20 18:32
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-01-20 19:12
Articles in Press	2014-05-23 10:30
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-21 12:08
Publish the Manuscript Online	2014-08-07 10:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	Aspirin inhibits cell viability and mTOR downstream signaling in gastroenteropancreatic and bronchopulmonary neuroendocrine tumor cells
Manuscript Source	Invited Manuscript
All Author List	Matilde Spampatti, George Vlotides, Gerald Spöttl, Julian Maurer, Burkhard Göke and Christoph J Auernhammer
Funding Agency and Grant Number
Corresponding Author	Dr. Christoph J Auernhammer, Department of Internal Medicine Ⅱ, University-Hospital Campus Grosshadern, Interdisciplinary Center of Neuroendocrine Tumours of the GastroEnteroPancreatic System (GEPNET-KUM), Ludwig-Maximilians-University of Munich, Marchioninistr 15, 81377 Munich, Germany. cauernha@med.uni-muenchen.de
Key Words	Neuroendocrine tumors; Aspirin; Cell Viability; Mammalian target of rapamycin protein
Core Tip	We evaluated the effects of aspirin on pancreatic (BON1), bronchopulmonary (NCI-H727) and midgut (GOT1) neuroendocrine tumor cell lines and demonstrated that aspirin has potent antitumor properties in vitro. Aspirin caused a dose-dependent reduction of cell viability/cell proliferation, the inhibition of targets downstream of mammalian target of rapamycin and the (compensatory) activation of the AKT and extracellular signal-regulated kinase signaling pathways. Treatment of BON1 and NCI-H727 cells with aspirin reduced the entry of these cells into the S phase of the cell cycle, and this effect was associated with the induction of p21 and reduced cyclin-dependent kinase 4 and cyclin D3 expression.
Publish Date	2014-08-07 10:34
Citation	Spampatti M, Vlotides G, Spöttl G, Maurer J, Göke B, Auernhammer CJ. Aspirin inhibits cell viability and mTOR downstream signaling in gastroenteropancreatic and bronchopulmonary neuroendocrine tumor cells. World J Gastroenterol 2014; 20(29): 10038-10049
URL	http://www.wjgnet.com/1007-9327/full/v20/i29/10038.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i29.10038

Full Article (PDF)	WJG-20-10038.pdf
Full Article (Word)	WJG-20-10038.doc
Manuscript File	4179-Review.docx
Answering Reviewers	4179-Answering reviewers.pdf
Copyright License Agreement	4179-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4179-Language certificate.pdf
Peer-review Report	4179-Peer review(s).pdf
Scientific Editor Work List	4179-Scientific editor work list.doc