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12/27/2018 8:56:32 AM | Browse: 785 | Download: 1098
Publication Name World Journal of Gastroenterology
Manuscript ID 41799
Country/Territory South Korea
Received
2018-08-27 03:30
Peer-Review Started
2018-08-27 03:56
To Make the First Decision
2018-10-24 01:51
Return for Revision
2018-10-24 08:27
Revised
2018-11-08 06:44
Second Decision
2018-11-13 08:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-11-13 21:56
Articles in Press
2018-11-13 21:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-11-19 21:22
Typeset the Manuscript
2018-12-24 09:36
Publish the Manuscript Online
2018-12-27 08:56
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Mismatched effects of receptor interacting protein kinase-3 on hepatic steatosis and inflammation in non-alcoholic fatty liver disease
Manuscript Source Unsolicited Manuscript
All Author List Waqar Khalid Saeed, Dae Won Jun, Kiseok Jang, Sang Bong Ahn, Ju Hee Oh, Yeon Ji Chae, Jai Sun Lee and Hyeon Tae Kang
ORCID
Author(s) ORCID Number
Waqar Khalid Saeed http://orcid.org/0000-0002-7888-9108
Dae Won Jun http://orcid.org/0000-0002-2875-6139
Kiseok Jang http://orcid.org/0000-0002-6585-3990
Sang Bong Ahn http://orcid.org/0000-0001-7419-5259
Ju Hee Oh http://orcid.org/0000-0003-3031-0272
Yeon Ji Chae http://orcid.org/0000-0001-7126-1070
Jai Sun Lee http://orcid.org/0000-0002-1673-8777
Hyeon Tae Kang http://orcid.org/0000-0002-0595-3025
Funding Agency and Grant Number
Funding Agency Grant Number
National Research Foundation NRF-2017R1C1B5074215
Corresponding Author Dae Won Jun, MD, PhD, Professor, Department of Internal Medicine, Hanyang University College of Medicine, 222-1 Wangsimni-ro, Seongdong-gu, Seoul 04763, South Korea. noshin@hanyang.ac.kr
Key Words Necroptosis; Receptor interacting protein kinase-3; Mixed lineage kinase domain-like protein; Non-alcoholic fatty liver disease; Steatosis
Core Tip Receptor interacting protein kinase-3 (RIP3) deletion was associated with increased fatty change, hepatic tissue triglycerides, body weight, and serum aspartate aminotransferase and alanine aminotransferase levels. Very-low-density lipoproteins secretion markers, including apolipoprotein-B, microsomal triglyceride transfer protein, and protein disulfide isomerase, were suppressed with RIP3 deletion. High fat diet fed RIP3KO mice had reduced expressions of tumor necrosis factor alpha and neutrophil chemokines [Chemokine (C-X-C motif) ligands: CXCL1, and CXCL2] compared to high fat diet fed wild-type mice. In vitro analysis suggests that necroptotic stimulation [lipopolysaccharide + N-Benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone] increased CXCL1/2 expression in monocytes. Treatment with RIP3 inhibitor (GSK’843) decreased the expression of CXCL1/2 as well as interleukin-6.
Publish Date 2018-12-27 08:56
Citation Saeed WK, Jun DW, Jang K, Ahn SB, Oh JH, Chae YJ, Lee JS, Kang HT. Mismatched effects of receptor interacting protein kinase-3 on hepatic steatosis and inflammation in non-alcoholic fatty liver disease. World J Gastroenterol 2018; 24(48): 5477-5490
URL https://www.wjgnet.com/1007-9327/full/v24/i48/5477.htm
DOI https://dx.doi.org/10.3748/wjg.v24.i48.5477
Full Article (PDF) WJG-24-5477.pdf
Full Article (Word) WJG-24-5477.docx
The ARRIVE Guidelines 41799-The ARRIVE guidelines.pdf
Manuscript File 41799-Review.docx
Answering Reviewers 41799-Answering reviewers.pdf
Audio Core Tip 41799-Audio core tip.mp3
Biostatistics Review Certificate 41799-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 41799-Conflict-of-interest statement.pdf
Copyright License Agreement 41799-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 41799-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 41799-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 41799-Non-Native Speakers of English Editing Certificate.docx
Peer-review Report 41799-Peer-review(s).pdf
Scientific Misconduct Check 41799-Scientific misconduct check.pdf
Scientific Editor Work List 41799-Scientific editor work list.pdf