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Articles Published Processes
12/27/2018 8:56:32 AM | Browse: 1209 | Download: 2303
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Received |
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2018-08-27 03:30 |
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Peer-Review Started |
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2018-08-27 03:56 |
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First Decision by Editorial Office Director |
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2018-10-24 01:02 |
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Return for Revision |
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2018-10-24 08:27 |
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Revised |
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2018-11-08 06:44 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2018-11-13 08:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2018-11-13 21:56 |
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Articles in Press |
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2018-11-13 21:56 |
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Edit the Manuscript by Language Editor |
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2018-11-19 21:22 |
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Typeset the Manuscript |
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2018-12-24 09:36 |
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Publish the Manuscript Online |
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2018-12-27 08:56 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Mismatched effects of receptor interacting protein kinase-3 on hepatic steatosis and inflammation in non-alcoholic fatty liver disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Waqar Khalid Saeed, Dae Won Jun, Kiseok Jang, Sang Bong Ahn, Ju Hee Oh, Yeon Ji Chae, Jai Sun Lee and Hyeon Tae Kang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Research Foundation |
NRF-2017R1C1B5074215 |
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| Corresponding Author |
Dae Won Jun, MD, PhD, Professor, Department of Internal Medicine, Hanyang University College of Medicine, 222-1 Wangsimni-ro, Seongdong-gu, Seoul 04763, South Korea. noshin@hanyang.ac.kr |
| Key Words |
Necroptosis; Receptor interacting protein kinase-3; Mixed lineage kinase domain-like protein; Non-alcoholic fatty liver disease; Steatosis |
| Core Tip |
Receptor interacting protein kinase-3 (RIP3) deletion was associated with increased fatty change, hepatic tissue triglycerides, body weight, and serum aspartate aminotransferase and alanine aminotransferase levels. Very-low-density lipoproteins secretion markers, including apolipoprotein-B, microsomal triglyceride transfer protein, and protein disulfide isomerase, were suppressed with RIP3 deletion. High fat diet fed RIP3KO mice had reduced expressions of tumor necrosis factor alpha and neutrophil chemokines [Chemokine (C-X-C motif) ligands: CXCL1, and CXCL2] compared to high fat diet fed wild-type mice. In vitro analysis suggests that necroptotic stimulation [lipopolysaccharide + N-Benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone] increased CXCL1/2 expression in monocytes. Treatment with RIP3 inhibitor (GSK’843) decreased the expression of CXCL1/2 as well as interleukin-6. |
| Publish Date |
2018-12-27 08:56 |
| Citation |
Saeed WK, Jun DW, Jang K, Ahn SB, Oh JH, Chae YJ, Lee JS, Kang HT. Mismatched effects of receptor interacting protein kinase-3 on hepatic steatosis and inflammation in non-alcoholic fatty liver disease. World J Gastroenterol 2018; 24(48): 5477-5490 |
| URL |
https://www.wjgnet.com/1007-9327/full/v24/i48/5477.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v24.i48.5477 |
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