Publication Name	World Journal of Gastroenterology
Manuscript ID	41811
Country	Czech Republic

Received	2018-08-31 11:28
Peer-Review Started	2018-09-02 06:20
To Make the First Decision	2018-10-08 02:37
Return for Revision	2018-10-14 06:41
Revised	2018-10-20 20:56
Second Decision	2018-11-13 08:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-11-13 21:53
Articles in Press	2018-11-13 21:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-11-16 05:57
Publish the Manuscript Online	2018-11-21 04:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Transplantation
Manuscript Type	Retrospective Study
Article Title	Risk of recurrence of primary sclerosing cholangitis after liver transplantation is associated with de novo inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	Lukas Bajer, Antonij Slavcev, Peter Macinga, Eva Sticova, Jan Brezina, Matej Roder, Radim Janousek, Pavel Trunecka, Julius Spicak and Pavel Drastich
ORCID	Author(s) ORCID Number Lukas Bajer http://orcid.org/0000-0002-3815-3120 Antonij Slavcev http://orcid.org/0000-0002-6154-9131 Peter Macinga http://orcid.org/0000-0003-3699-6914 Eva Sticova http://orcid.org/0000-0003-2486-6266 Jan Brezina http://orcid.org/0000-0002-0440-9220 Matej Roder http://orcid.org/0000-0002-3677-3473 Radim Janousek http://orcid.org/0000-0003-2735-9403 Pavel Trunecka http://orcid.org/0000-0002-4753-4419 Julius Spicak http://orcid.org/0000-0002-3823-2881 Pavel Drastich http://orcid.org/0000-0002-5656-9242
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Health of the Czech Republic 15-28064A Ministry of Health of the Czech Republic 16-27477A
Corresponding Author	Lukas Bajer, MD, Doctor, Doctor, Department of Gastroenterology and Hepatology, Institute for Clinical and Experimental Medicine, Videnska 9, Prague 14021, Czech Republic. lukasbajer1@gmail.com
Key Words	Primary sclerosing cholangitis; Inflammatory bowel disease; Liver transplantation; Acute cellular rejection; Autoimmune hepatitis; Human leukocyte antigen; Immunosuppression
Core Tip	This study demonstrates that patients with de novo colitis after liver transplantation for primary sclerosing cholangitis (PSC) are significantly predisposed towards primary liver disease recurrence (rPSC). History of acute cellular rejection of the liver graft, overlapping features of autoimmune hepatitis (autoimmune hepatitis /PSC) and certain human leukocyte antigen (HLA)-DQ and HLA-DR alleles in both donors and recipients may also have an impact on rPSC development. These data based on analysis of well-defined cohort with long median follow-up suggest that thorough routine endoscopic, radiological and immunological examination (both pre- and post-transplant) is crucial for identifying high-risk patients.
Publish Date	2018-11-21 04:08
Citation	Bajer L, Slavcev A, Macinga P, Sticova E, Brezina J, Roder M, Janousek R, Trunecka P, Spicak J, Drastich P. Risk of recurrence of primary sclerosing cholangitis after liver transplantation is associated with de novo inflammatory bowel disease. World J Gastroenterol 2018; 24(43): 4939-4949
URL	http://www.wjgnet.com/1007-9327/full/v24/i43/4939.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i43.4939

Full Article (PDF)	WJG-24-4939.pdf
Full Article (Word)	WJG-24-4939.doc
Manuscript File	41811-Review.docx
Answering Reviewers	41811-Answering reviewers.pdf
Audio Core Tip	41811-Audio core tip.mp3
Biostatistics Review Certificate	41811-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	41811-Conflict-of-interest statement.pdf
Copyright License Agreement	41811-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	41811-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	41811-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	41811-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	41811-Language certificate.pdf
Peer-review Report	41811-Peer-review(s).pdf
Scientific Misconduct Check	41811-Scientific misconduct check.pdf
Scientific Editor Work List	41811-Scientific editor work list.pdf