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Articles Published Processes
11/13/2018 8:04:45 AM | Browse: 990 | Download: 1223
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Received |
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2018-08-28 02:13 |
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Peer-Review Started |
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2018-08-28 08:00 |
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To Make the First Decision |
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2018-10-08 03:57 |
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Return for Revision |
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2018-10-09 02:41 |
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Revised |
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2018-10-10 21:48 |
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Second Decision |
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2018-10-19 09:31 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2018-10-21 06:33 |
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Articles in Press |
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2018-10-21 06:33 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-11-09 05:54 |
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Publish the Manuscript Online |
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2018-11-13 08:04 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Liver as a target of human immunodeficiency virus infection
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Murali Ganesan, Larisa I Poluektova, Kusum K Kharbanda and Natalia A Osna |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Nebraska Research Institute Grant |
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| Corresponding Author |
Natalia A Osna, MD, PhD, Associate Professor, Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, 4101 Woolworth Ave, Omaha, NE 68105, United States. nosna@unmc.edu |
| Key Words |
Liver cells; Antiretroviral therapy; Apoptosis; Inflammation; Fibrosis; Immunodeficiency virus; Alcohol |
| Core Tip |
Here, we summarized the literature and our recent findings on human immunodeficiency virus (HIV)-related liver damage. Liver injury is the second and most frequent cause of HIV patients’ death after acquired immune deficiency syndrome. The results of clinical studies support close association between HIV severity and liver disease progression. It is clear now that both liver parenchymal and non-parenchymal cells play a significant role in HIV-triggered liver inflammation and fibrosis pathogenesis and might serve as reservoirs of HIV-infection. Hepatotoxicity comes from the direct interactions between HIV and liver cells as well as from harmful effects of anti-retroviral therapy potentiated by second insults, like alcohol. |
| Publish Date |
2018-11-13 08:04 |
| Citation |
Ganesan M, Poluektova LY, Kharbanda KK, Osna NA. Liver as a target of human immunodeficiency virus infection. World J Gastroenterol 2018; 24(42): 4728-4737 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i42/4728.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i42.4728 |
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