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11/13/2018 8:04:45 AM | Browse: 404 | Download: 339
Publication Name World Journal of Gastroenterology
Manuscript ID 41844
Country/Territory United States
2018-08-28 02:13
Peer-Review Started
2018-08-28 08:00
To Make the First Decision
2018-10-08 03:57
Return for Revision
2018-10-09 02:41
2018-10-10 21:48
Second Decision
2018-10-19 09:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-10-21 06:33
Articles in Press
2018-10-21 06:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-11-09 05:54
Publish the Manuscript Online
2018-11-13 08:04
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Liver as a target of human immunodeficiency virus infection
Manuscript Source Invited Manuscript
All Author List Murali Ganesan, Larisa I Poluektova, Kusum K Kharbanda and Natalia A Osna
Author(s) ORCID Number
Murali Ganesan http://orcid.org/0000-0002-2981-568X
Larisa I Poluektova http://orcid.org/0000-0001-7339-8732
Kusum K Kharbanda http://orcid.org/0000-0001-7759-8889
Natalia A Osna http://orcid.org/0000-0001-7498-0556
Funding Agency and Grant Number
Funding Agency Grant Number
Nebraska Research Institute Grant
Corresponding Author Natalia A Osna, MD, PhD, Associate Professor, Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, 4101 Woolworth Ave, Omaha, NE 68105, United States. nosna@unmc.edu
Key Words Liver cells; Antiretroviral therapy; Apoptosis; Inflammation; Fibrosis; Immunodeficiency virus; Alcohol
Core Tip Here, we summarized the literature and our recent findings on human immunodeficiency virus (HIV)-related liver damage. Liver injury is the second and most frequent cause of HIV patients’ death after acquired immune deficiency syndrome. The results of clinical studies support close association between HIV severity and liver disease progression. It is clear now that both liver parenchymal and non-parenchymal cells play a significant role in HIV-triggered liver inflammation and fibrosis pathogenesis and might serve as reservoirs of HIV-infection. Hepatotoxicity comes from the direct interactions between HIV and liver cells as well as from harmful effects of anti-retroviral therapy potentiated by second insults, like alcohol.
Publish Date 2018-11-13 08:04
Citation Ganesan M, Poluektova LY, Kharbanda KK, Osna NA. Liver as a target of human immunodeficiency virus infection. World J Gastroenterol 2018; 24(42): 4728-4737
Url http://www.wjgnet.com/1007-9327/full/v24/i42/4728.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i42.4728
Full Article (PDF) WJG-24-4728.pdf
Full Article (Word) WJG-24-4728.doc
Manuscript File 41844-Review.docx
Answering Reviewers 41844-Answering reviewers.pdf
Audio Core Tip 41844-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 41844-Conflict-of-interest statement.pdf
Copyright License Agreement 41844-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 41844-Grant application form(s).pdf
Peer-review Report 41844-Peer-review(s).pdf
Scientific Misconduct Check 41844-Scientific misconduct check.pdf
Scientific Editor Work List 41844-Scientific editor work list.pdf