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12/6/2018 1:35:45 PM | Browse: 246 | Download: 248
Publication Name World Journal of Clinical Cases
Manuscript ID 41974
Country/Territory Japan
2018-09-03 08:24
Peer-Review Started
2018-09-03 12:14
To Make the First Decision
2018-10-15 01:53
Return for Revision
2018-10-15 03:23
2018-10-26 12:12
Second Decision
2018-11-14 09:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-11-15 02:43
Articles in Press
2018-11-15 02:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-11-30 01:49
Publish the Manuscript Online
2018-12-06 13:35
ISSN 2307-8960 (online)
Open Access This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Inflammation and de-differentiation in pancreatic carcinogenesis
Manuscript Source Invited Manuscript
All Author List Takahiro Seimiya, Motoyuki Otsuka, Takuma Iwata, Eri Tanaka, Tatsunori Suzuki, Kazuma Sekiba, Mari Yamagami, Rei Ishibashi and Kazuhiko Koike
Author(s) ORCID Number
Takahiro Seimiya http://orcid.org/0000-0003-1698-030
Motoyuki Otsuka http://orcid.org/0000-0003-2869-2881
Takuma Iwata http://orcid.org/0000-0001-5229-3042
Eri Tanaka http://orcid.org/0000-0001-5823-0472
Tatsunori Suzuki http://orcid.org/0000-0002-2344-7732
Kazuma Sekiba http://orcid.org/0000-0002-9429-1974
Mari Yamagami http://orcid.org/0000-0002-1533-8245
Rei Ishibashi http://orcid.org/0000-0002-9649-6471
Kazuhiko Koike http://orcid.org/0000-0002-9739-9243
Funding Agency and Grant Number
Funding Agency Grant Number
Research Program on Hepatitis from Japan Agency for Medical Research and Development, AMED JP18fk0210214
Project for Cancer Research and Therapeutic Evolution (P-CREATE) from AMED JP19cm0106602
Corresponding author Motoyuki Otsuka, MD, PhD, Assistant Professor, Doctor, Lecturer, Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku 113-8655, Japan. otsukamo-tky@umin.ac.jp
Keywords Pancreatitis; Inflammation; Organogenesis; Differentiation; Transcription factor; Pancreatic cancer
Core Tip Inflammation is involved in carcinogenesis by causing DNA damage. Recent studies show that carcinogenesis is promoted by reprogramming factors and by suppressing transcription factors related to acinar cell differentiation. Pancreatitis also shows such transcriptional changes, suggesting that epigenetic changes by several causes leading to the impaired differentiation may constitute an important framework for pancreatic carcinogenesis. New diagnostic, preven­tive and/or treatment strategies based on the findings described in this review are expected to be clinically applied in the near future.
Publish Date 2018-12-06 13:35
Citation Seimiya T, Otsuka M, Iwata T, Tanaka E, Suzuki T, Sekiba K, Yamagami M, Ishibashi R, Koike K. Inflammation and de-differentiation in pancreatic carcinogenesis. World J Clin Cases 2018; 6(15): 882-891
Url http://www.wjgnet.com/2307-8960/full/v6/i15/882.htm
DOI http://dx.doi.org/10.12998/wjcc.v6.i15.882
Full Article (PDF) WJCC-6-882.pdf
Full Article (Word) WJCC-6-882.doc
Manuscript File 41974-Review.doc
Answering Reviewers 41974-Answering reviewers.pdf
Audio Core Tip 41974-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 41974-Conflict-of-interest statement.pdf
Copyright License Agreement 41974-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 41974-Language certificate.pdf
Peer-review Report 41974-Peer-review(s).pdf
Scientific Misconduct Check 41974-Scientific misconduct check.pdf
Scientific Editor Work List 41974-Scientific editor work list.pdf